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Citation
Tags
HERO ID
1677622
Reference Type
Journal Article
Title
Interaction effects of lead on bioavailability and pharmacokinetics of arsenic in the rat
Author(s)
Diacomanolis, V; Noller, BN; Ng, JC
Year
2013
Is Peer Reviewed?
Yes
Journal
Environmental Geochemistry and Health
ISSN:
0269-4042
EISSN:
1573-2983
Volume
35
Issue
6
Page Numbers
757-766
Language
English
PMID
23728997
DOI
10.1007/s10653-013-9527-x
Web of Science Id
WOS:000326055000006
Abstract
Arsenic (As) and lead (Pb) are common contaminants found in mine waste materials. For an evidence-based risk assessment, it is important to better understand the potential interaction of mixed contaminants; and this interaction study was investigated in an in vivo rat model. Following co-administration of a fixed dose of As(V) as in sodium arsenate and different doses of Pb as lead acetate to Sprague-Dawley rats, blood arsenic concentration and bioavailability decreased. A decrease in As blood concentration when lead was co-administered was observed with increasing lead doses. Pharmacokinetic parameters for As in the blood showed faster absorption and elimination of this metalloid in the presence of Pb. The elimination half-life of As decreased from 67 days in As solo group to 27-30 with doses of Pb. Bioavailability of As was also decreased by 30-43 % in the presence of Pb. Decreased urinary excretion of Pb and tissue accumulation were also observed. It indicates lower absorption of As when co-administered with Pb. A probable explanation for these findings is that As co-administration with Pb could have resulted in the formation of less soluble lead arsenate. However, such an interaction between As and Pb could only explain about one-third of the variation when real mine waste materials containing both of these elements were administered to rats. This suggests that other effects from physical and chemical parameters could contribute to the bioavailability of arsenic in complex real environmental samples.
Tags
IRIS
•
Arsenic Hazard ID
PubMed
Considered New
ToxNet
Considered New
PubMed
ToxNet
Excluded
Toxnet Duplicates
PubMed
ToxNet
Excluded
Toxnet Duplicates
2. Lit Search Updates through Oct 2015
PubMed
ToxNet
Considered
7. Other Studies through Oct 2015
PBPK/TK
Susceptibility Category
Coexposure
Health Effect Category
Not Relevant
•
Arsenic (Inorganic)
1. Literature
Lit search updates through Oct 2015
3. Hazard ID Screening
Other potentially supporting studies
5. Susceptibility Screening
Relevant
Animal
•
Arsenic Susceptibility
4. Susceptibility and Lifestages
Coexposure
5. Health Effect
Not Relevant
1. Susceptibility Literature Screening
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