Health & Environmental Research Online (HERO)


Print Feedback Export to File
1677622 
Journal Article 
Interaction effects of lead on bioavailability and pharmacokinetics of arsenic in the rat 
Diacomanolis, V; Noller, BN; Ng, JC 
In Press 
Yes 
Environmental Geochemistry and Health
ISSN: 0269-4042
EISSN: 1573-2983 
35 
757-766 
English 
Arsenic (As) and lead (Pb) are common contaminants found in mine waste materials. For an evidence-based risk assessment, it is important to better understand the potential interaction of mixed contaminants; and this interaction study was investigated in an in vivo rat model. Following co-administration of a fixed dose of As(V) as in sodium arsenate and different doses of Pb as lead acetate to Sprague-Dawley rats, blood arsenic concentration and bioavailability decreased. A decrease in As blood concentration when lead was co-administered was observed with increasing lead doses. Pharmacokinetic parameters for As in the blood showed faster absorption and elimination of this metalloid in the presence of Pb. The elimination half-life of As decreased from 67 days in As solo group to 27-30 with doses of Pb. Bioavailability of As was also decreased by 30-43 % in the presence of Pb. Decreased urinary excretion of Pb and tissue accumulation were also observed. It indicates lower absorption of As when co-administered with Pb. A probable explanation for these findings is that As co-administration with Pb could have resulted in the formation of less soluble lead arsenate. However, such an interaction between As and Pb could only explain about one-third of the variation when real mine waste materials containing both of these elements were administered to rats. This suggests that other effects from physical and chemical parameters could contribute to the bioavailability of arsenic in complex real environmental samples. 
IRIS
• Arsenic Hazard ID
          PubMed
          Considered New
          ToxNet
          Considered New
          PubMed
          ToxNet
          Excluded
               Toxnet Duplicates
          PubMed
          ToxNet
          Excluded
               Toxnet Duplicates
     2. Lit Search Updates through Oct 2015
          PubMed
          ToxNet
          Considered
     7. Other Studies through Oct 2015
          PBPK/TK
          Susceptibility Category
               Coexposure
          Health Effect Category
               Not Relevant
• Arsenic (Inorganic)
     1. Literature
          Lit search updates through Oct 2015
     3. Hazard ID Screening
          Other potentially supporting studies
     5. Susceptibility Screening
          Relevant
               Animal
• Arsenic Susceptibility
     4. Susceptibility and Lifestages
          Coexposure
     5. Health Effect
          Not Relevant
     1. Susceptibility Literature Screening
          Keyword Search