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HERO ID
197322
Reference Type
Journal Article
Title
Intellectual impairment in children exposed to polychlorinated biphenyls in utero
Author(s)
Jacobson, JL; Jacobson, SW
Year
1996
Is Peer Reviewed?
1
Journal
New England Journal of Medicine
ISSN:
0028-4793
EISSN:
1533-4406
Report Number
NIOSH/00236088
Volume
335
Issue
11
Page Numbers
783-789
Language
English
PMID
8703183
DOI
10.1056/NEJM199609123351104
Web of Science Id
WOS:A1996VF78600004
URL
http://
://WOS:A1996VF78600004
Exit
Relationship(s)
is also published as
2189885
Intellectual impairment in children exposed to polychlorinated biphenyls in utero
Abstract
Background In utero exposure to polychlorinated biphenyls, a ubiquitous environmental contaminant, has been linked to adverse effects on neurologic and intellectual function in infants and young children. We assessed whether these effects persist through school age and examined their importance in the acquisition of reading and arithmetic skills.
Methods We tested 212 children, recruited as newborns to overrepresent infants born to women who had eaten Lake Michigan fish contaminated with polychlorinated biphenyls. A battery of IQ and achievement tests was administered when the children were 11 years of age. Concentrations of polychlorinated biphenyls in maternal serum and milk at delivery were slightly higher than in the general population. A composite measure of prenatal exposure was derived from concentrations in umbilical-cord serum and maternal serum and milk.
Results Prenatal exposure to polychlorinated biphenyls was associated with lower full-scale and verbal IQ scores after control for potential confounding variables such as socioeconomic status (P = 0.02). The strongest effects related to memory and attention. The most highly exposed children were three times as likely to have low average IQ scores (P<0.001) and twice as likely to be at least two years behind in reading comprehension (P = 0.03). Although larger quantities of polychlorinated biphenyls are transferred by breast-feeding than in utero, there were deficits only in association with transplacental exposure, suggesting that the developing fetal brain is particularly sensitive to these compounds.
Conclusions In utero exposure to polychlorinated biphenyls in concentrations slightly higher than those in the general population can have a long-term impact on intellectual function.
Keywords
BIOCHEMISTRY; DIET; IATROGENIC DISEASE; NERVOUS SYSTEM DISEASES/PATHOLOGY; MENTAL DISORDERS/THERAPY; MENTAL DISORDERS/PATHOLOGY; PSYCHOPATHOLOGY; FOOD ADDITIVES/POISONING; FOOD ADDITIVES/TOXICITY; FOOD CONTAMINATION; FOOD POISONING; FOOD PRESERVATIVES/POISONING; FOOD PRESERVATIVES/TOXICITY; ENVIRONMENTAL POLLUTANTS/POISONING; OCCUPATIONAL DISEASES; CHILD DEVELOPMENT; PEDIATRICS; ANIMAL; EMBRYO; FETAL DISEASES; HUMAN; LARVA; EMBRYOLOGY; CELL DIFFERENTIATION; FETAL DEVELOPMENT; MORPHOGENESIS; HOMINIDAE; Biochemical Studies-General; Nutrition-Pathogenic Diets; Nervous System-Pathology; Psychiatry-Psychopathology; Toxicology-Foods; Toxicology-Environmental and Industrial Toxicology; Developmental Biology-Embryology-Pathological; Developmental Biology-Embryology-Morphogenesis; 39765-80-5; 27304-13-8; 2385-85-5; 1024-57-3; 319-85-7; 118-74-1; 50-29-3
Tags
IRIS
•
Formaldehyde [archived]
Reproductive and Developmental Effects
Screened
Title/abstract
Not formaldehyde
Retroactive RIS import
2015
FA DevRepro 072115
Not FA-Exposure Criteria
Not FA-Exposure Criteria
•
IRIS Formaldehyde (Inhalation) [Final 2024]
Literature Indexing
Other sources and cited references
Literature Identification
Reproductive and Developmental Effects
Excluded
•
PCBs
Hazard ID: Epidemiological evidence
Litsearches
PubMed
WoS
ToxLine
Remaining
LitSearch August 2015
Pubmed
Toxline
WoS
Cited (Nov 2012)
Seed References
•
PCBs Epi Hazard ID
Health Effects
Neurological
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