Jump to main content
US EPA
United States Environmental Protection Agency
Search
Search
Main menu
Environmental Topics
Laws & Regulations
About EPA
Health & Environmental Research Online (HERO)
Contact Us
Print
Feedback
Export to File
Search:
This record has one attached file:
Add More Files
Attach File(s):
Display Name for File*:
Save
Citation
Tags
HERO ID
198076
Reference Type
Journal Article
Title
Effects of polychlorinated biphenyl/dioxin exposure and feeding type on infants' mental and psychomotor development
Author(s)
Koopman-Esseboom, C; Weisglas-Kuperus, N; de Ridder, MAJ; Van der Paauw, CG; Tuinstra, LGM; Sauer, PJJ
Year
1996
Is Peer Reviewed?
1
Journal
Pediatrics
ISSN:
0031-4005
EISSN:
1098-4275
Volume
97
Issue
5
Page Numbers
700-706
Language
English
PMID
8628610
DOI
10.1542/peds.97.5.700
Web of Science Id
WOS:A1996UH75800016
Relationship(s)
has comment/response
6866756
[Email to Krista Christensen regarding a request for information on Koopman-Esseboom et al., 1996]
Abstract
OBJECTIVE: To evaluate the effects of in utero and lactational exposure to polychlorinated biphenyls (PCBs) and dioxins on the mental and psychomotor development of infants.
DESIGN: Prenatal PCB exposure was estimated from the levels in maternal plasma during the last month of pregnancy. Postnatal PCB and dioxin exposure of breastfed infants was calculated from levels in human milk samples and the duration of breastfeeding. Infants were examined at 3, 7, and 18 months of age with the Bayley Scales of Infant Development.
SETTING: General community.
PARTICIPANTS: Voluntary sample of 207 mother-infant pairs. One hundred five infants were breastfed and 102 were bottle-fed.
INTERVENTIONS: None.
RESULTS: Higher in utero exposure to PCBs was associated with lower psychomotor scores at 3 months of age: a doubling of the PCB load resulted in a decrease of 3 points. Breastfed infants scored significantly higher on the psychomotor score at 7 months of age, compared with formula-fed infants. However, when corrected for confounders, the psychomotor score of the 66% highest-exposed breastfed infants ( > 756 pg total PCB-dioxin toxic equivalent) was negatively influenced by this postnatal exposure to PCBs and dioxins, and was comparable to the psychomotor score of the formula-fed infants. Breastfed infants also scored higher on the mental scale at 7 months of age in a dose-dependent way. There was no significant influence of the perinatal PCB and dioxin exposure on the mental outcome at 3 and 7 months of age. At 18 months of age neither the mental nor the psychomotor score was related to perinatal PCB or dioxin exposure, nor to the duration of breastfeeding.
CONCLUSIONS: Prenatal PCB exposure has a small negative effect on the psychomotor score at 3 months of age. PCB and dioxin exposure through breastfeeding has an adverse effect on the psychomotor outcome at 7 months of age. The mental outcome at 7 months of age is positively influenced by breastfeeding per se; the perinatal exposure to PCBs and dioxins does not influence this outcome. At 18 months of age the development is affected neither by PCB and dioxin exposure nor by feeding type.
Tags
IRIS
•
Dioxin (2012 Project Page for Final Report)
•
PCBs
Hazard ID: Epidemiological evidence
Litsearches
PubMed
WoS
ToxLine
Remaining
LitSearch August 2015
Pubmed
Toxline
WoS
Cited (Nov 2012)
Seed References
•
PCBs Epi Hazard ID
Health Effects
Neurological
Home
Learn about HERO
Using HERO
Search HERO
Projects in HERO
Risk Assessment
Transparency & Integrity