US EPA

2241690 

Journal Article 

Optimisation of an analytical method and results from the inter-laboratory comparison of the migration of regulated substances from food packaging into the new mandatory European Union simulant for dry foodstuffs 

Jakubowska, N; Beldì, G; Peychès Bach, A; Simoneau, C 

2014 

1 

Food Additives & Contaminants: Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
ISSN: 1944-0049
EISSN: 1944-0057 

Taylor and Francis Ltd. 

Abingdon 

31 

3 

546-555 

English 

24409838 

10.1080/19440049.2013.874046 

WOS:000333878500016 

https://www.proquest.com/scholarly-journals/optimisation-analytical-method-results-inter/docview/1513358422/se-2?accountid=171501
Exit
 

This paper presents the outcome of the development, optimisation and validation at European Union level of an analytical method for using poly(2,6-diphenyl phenylene oxide - PPPO), which is stipulated in Regulation (EU) No. 10/2011, as food simulant E for testing specific migration from plastics into dry foodstuffs. Two methods for fortifying respectively PPPO and a low-density polyethylene (LDPE) film with surrogate substances that are relevant to food contact were developed. A protocol for cleaning the PPPO and an efficient analytical method were developed for the quantification of butylhydroxytoluene (BHT), benzophenone (BP), diisobutylphthalate (DiBP), bis(2-ethylhexyl) adipate (DEHA) and 1,2-cyclohexanedicarboxylic acid, diisononyl ester (DINCH) from PPPO. A protocol for a migration test from plastics using small migration cells was also developed. The method was validated by an inter-laboratory comparison (ILC) with 16 national reference laboratories for food contact materials in the European Union. This allowed for the first time data to be obtained on the precision and laboratory performance of both migration and quantification. The results showed that the validation ILC was successful even when taking into account the complexity of the exercise. The results showed that the method performance was 7-9% repeatability standard deviation (rSD) for most substances (regardless of concentration), with 12% rSD for the high level of BHT and for DiBP at very low levels. The reproducibility standard deviation results for the 16 European Union laboratories were in the range of 20-30% for the quantification from PPPO (for the three levels of concentrations of the five substances) and 15-40% from migration experiments from the fortified plastic at 60°C for 10 days and subsequent quantification. Considering the lack of data previously available in the literature, this work has demonstrated that the validation of a method is possible both for migration from a film and for quantification into a corresponding simulant for specific migration. 

migration; food contact materials; migrants; foods; contaminants; packaging; dry foods; Tenax; analytical methods; interlaboratory; comparisons; validation