Boyland, E; Busby, ER; Dukes, CE; Grover, PL; Manson, D
1. Magnesium stearate, n-hexadecanol, n-octadecanol and naphthalene have been tested for their suitability as a base for pellets implanted into the bladder of mice, but were not found to have any advantages over cholesterol. 2. Compounds which have been tested for carcinogenicity by bladder implantation in cholesterol pellets and which gave positive results include 4-aminoantipyrene, 4-acetamido-2′-hydroxy-6′-methylazobenzene (Celliton Yellow), 4-dimethylamino- 3-hydroxyazobenzene, 2-acetamidonaphthalene, bi8-(2-amino--1-naphthyl) phosphate, 3-methoxyanthranilic acid, hydroquinone and 2-fluorenylhydroxylamine. 3. 1-Naphthylhydroxylamine and 2-naphthylhydroxylamine gave positive results when tested in stearic acid pellets. 4. 1-Methoxy-2-naphthylamine produced tumours when implanted in pellets of magnesium stearate. We wish to thank Dr. R. Nery and Mr. J. W. Gorrod for preparing some of the compounds used and Mr. E. WooLlard and Mr. K. Robinson for skilled technical assistance. This investigation has been supported by grants to the Chester Beatty Research Institute (Institute of Cancer Research: Royal Cancer Hospital) from the Medical Research Council, the British Empire Cancer Campaign for Research, and the National Cancer Institute of the National Institutes of Health, U.S. Public Health Service. © 1964, The British Empire Cancer Campaign for Research. All rights reserved.
