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Citation
Tags
HERO ID
3350192
Reference Type
Journal Article
Subtype
Review
Title
Approaches to children's exposure assessment: Case study with diethylhexylphthalate (DEHP)
Author(s)
Ginsberg, G; Ginsberg, J; Foos, B
Year
2016
Is Peer Reviewed?
Yes
Journal
International Journal of Environmental Research and Public Health
ISSN:
1661-7827
EISSN:
1660-4601
Publisher
MDPI AG
Location
BASEL
Volume
13
Issue
7
Page Numbers
670
Language
English
PMID
27376320
DOI
10.3390/ijerph13070670
Web of Science Id
WOS:000380759800046
URL
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84977581607&doi=10.3390%2fijerph13070670&partnerID=40&md5=95b5d806d9f0d2345cb06ea08feb0340
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Abstract
Children's exposure assessment is a key input into epidemiology studies, risk assessment and source apportionment. The goals of this article are to describe a methodology for children's exposure assessment that can be used for these purposes and to apply the methodology to source apportionment for the case study chemical, diethylhexylphthalate (DEHP). A key feature is the comparison of total (aggregate) exposure calculated via a pathways approach to that derived from a biomonitoring approach. The 4-step methodology and its results for DEHP are: (1) Prioritization of life stages and exposure pathways, with pregnancy, breast-fed infants, and toddlers the focus of the case study and pathways selected that are relevant to these groups; (2) Estimation of pathway-specific exposures by life stage wherein diet was found to be the largest contributor for pregnant women, breast milk and mouthing behavior for the nursing infant and diet, house dust, and mouthing for toddlers; (3) Comparison of aggregate exposure by pathways vs biomonitoring-based approaches wherein good concordance was found for toddlers and pregnant women providing confidence in the exposure assessment; (4) Source apportionment in which DEHP presence in foods, children's products, consumer products and the built environment are discussed with respect to early life mouthing, house dust and dietary exposure. A potential fifth step of the method involves the calculation of exposure doses for risk assessment which is described but outside the scope for the current case study. In summary, the methodology has been used to synthesize the available information to identify key sources of early life exposure to DEHP.
Keywords
children; pregnancy; breast milk; house dust; contaminants; exposure assessment; plasticizer; phthalate; DEHP
Tags
IRIS
•
Dibutyl Phthalate (DBP)
Database Searches
Litsearch Jan 2016 - July 2016
Pubmed
Excluded: No Primary Data on Health Effects
Exposure levels
•
Phthalates – Targeted Search for Epidemiological Studies
Source – all searches
Pubmed
WOS
Excluded
Source - Dec 2016 Update (Private)
Pubmed
WOS
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