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3469376 
Journal Article 
Review 
A global assessment of phthalates burden and related links to health effects 
Katsikantami, I; Sifakis, S; Tzatzarakis, MN; Vakonaki, E; Kalantzi, OI; Tsatsakis, AM; Rizos, AK 
2016 
1 
Environment International
ISSN: 0160-4120
EISSN: 1873-6750 
PERGAMON-ELSEVIER SCIENCE LTD 
OXFORD 
97 
212-236 
English 
27669632 
WOS:000389912900025 
Phthalates are ubiquitous environmental contaminants which are used in industry as plasticizers and additives in cosmetics. They are classified as Endocrine Disrupting Chemicals (EDCs) which impair the human endocrine system inducing fertility problems, respiratory diseases, childhood obesity and neuropsychological disorders. The aim of this review is to summarize the current state of knowledge on the toxicity that phthalates pose in humans based on human biomonitoring studies conducted over the last decade. Except for conventional biological matrices (such as urine and serum), amniotic fluid, human milk, semen, saliva, sweat, meconium and human hair are also employed for the estimation of exposure and distribution of pollutants in the human body, although data are not enough yet. Children are highly exposed to phthalates relative to adults and in most studies children's daily intake surpasses the maximum reference dose (RfD) set from US Environmental Protection Agency (US EPA). However, the global trend is that human exposure to phthalates is decreasing annually as a result of the strict regulations applied to phthalates. 
Pollution Abstracts; Environment Abstracts; Toxicology Abstracts; 2OH-MiBP mono 2-hydroxy-isobutyl phthalate 
IRIS
• Dibutyl Phthalate (DBP)
     Database Searches
          LitSearch Jul 2016 - Jan 2017
               Considered new
               WoS
• Phthalates – Targeted Search for Epidemiological Studies
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          Pubmed
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     Source - Dec 2016 Update (Private)
          Pubmed