US EPA

3981482 

Journal Article 

Chronic exposure to perfluorooctane sulfonate reduces lifespan of Caenorhabditis elegans through insulin/IGF-1 signaling 

Xu, T; Li, P; Wu, S; Li, D; Wu, J; Raley-Susman, KM; He, D 

2016 

Yes 

Bulletin of Environmental Contamination and Toxicology
ISSN: 0007-4861
EISSN: 1432-0800 

97 

1 

119-123 

English 

27095033 

10.1007/s00128-016-1808-5 

WOS:000378779300020 

has data used in 5469475 Tris(2-chloroethyl) phosphate (TCEP) and tris(2-chloropropyl) phosphate (TCPP) induce locomotor deficits and dopaminergic degeneration in Caenorhabditis elegans

Perfluorooctane sulfonate (PFOS) is a persistent organic pollutant. Although multiple adverse effects of PFOS have been demonstrated, whether PFOS can accelerate aging and affect animal longevity remains unknown. In Caenorhabditis elegans, we found that a 50 h exposure to 0.2-200 µM PFOS reduced lifespan in a concentration dependent manner. In transgenic nematodes, lifespans are affected by mutations of daf-16, daf-2 or age-1 genes, which are related to the Insulin/IGF-1 Signaling pathway (IIS). PFOS exposure caused an additional reduction in average lifespan in daf-2(e1370) and daf-16b(KO) nematodes. In contrast, daf-16(mu86) nematodes showed no additional reduction with PFOS exposure and age-1(hx546) mutants did not exhibit a reduction in lifespan with PFOS exposure, compared with wildtype nematodes. Overall, our findings demonstrate that PFOS exposure accelerates aging and shortens longevity of animals. The PFOS-induced effect may involve genes of the IIS pathway, particularly daf-16 and age-1. 

Perfluorooctane sulfonate; Caenorhabditis elegans; Lifespan; IIS signaling; Daf-16; Age-1