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Citation
Tags
HERO ID
4238317
Reference Type
Journal Article
Title
Time trends in per- and polyfluoroalkyl substances (PFASs) in California women: Declining serum levels, 2011-2015
Author(s)
Hurley, S; Goldberg, D; Wang, M; Park, JS; Petreas, M; Bernstein, L; Anton-Culver, H; Nelson, DO; Reynolds, P
Year
2018
Is Peer Reviewed?
1
Journal
Environmental Science & Technology
ISSN:
0013-936X
EISSN:
1520-5851
Publisher
AMER CHEMICAL SOC
Location
WASHINGTON
Volume
52
Issue
1
Page Numbers
277-287
Language
English
PMID
29198103
DOI
10.1021/acs.est.7b04650
Web of Science Id
WOS:000419419500031
URL
https://search.proquest.com/docview/1990367766?accountid=171501
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Abstract
After several decades of widespread use, some per- and polyfluoroalkyl substances (PFASs) were phased-out of use due to concerns raised by their persistent, bioaccumulative, and toxic properties. Our objective was to evaluate temporal trends in serum PFAS levels among 1257 middle-aged and older California women (ages 40-94) during a four year period, beginning approximately 5-10 years after these phase-outs began. An online SPE-HPLC-MS/MS was used to measure 10 long-chain PFASs in serum from blood collected cross-sectionally during 2011-2015 from a subset of participants in the California Teachers Study. Results from multivariable linear regression analyses indicated that serum concentrations of nearly all PFASs declined on average 10% to 20% per year. Serum levels of perfluorohexanesulfonic acid (PFHxS) did not significantly decline. With the exception of PFHxS, the downward trend in serum concentrations was evident for all PFASs across all ages, although declines were comparatively steeper among the oldest women. These findings suggest that the phase-out of some common PFASs has resulted in reduced human exposures to them. The lack of a decline for PFHxS suggests that these exposures may be ongoing and underscores the importance of continued biomonitoring and research efforts to elucidate current pathways of exposure.
Keywords
Environmental Studies; Regression analysis; Human exposure; Older people; Bioaccumulation; Serum levels; Exposure; Biomonitoring; Liquid chromatography; High-performance liquid chromatography; California
Tags
PFAS
•
Additional PFAS (formerly XAgency)
Literature Search November 2019
Other Sources
Reference list review of included studies
Screened Studies
Excluded
Exclude (TIAB)
•
Expanded PFAS SEM (formerly PFAS 430)
Litsearch: September 2019
Web of Science
Screened Studies
Supplemental
Perfluorooctane
•
PFAS 150
Literature Search Update December 2020
PubMed
WOS
Literature Search August 2019
PubMed
Web of Science
Not prioritized for screening
Perfluorinated compounds
Perfluorohexanesulfonic acid
Perfluorooctane
•
PFDA
Scopus: April 2021
•
PFHxS
Database searches
Pubmed
Toxline
WOS
Scopus
Inclusion
TiAb
Supplemental
Full Text
Exposure assessment or characterization (no health outcome)
•
PFNA
Litsearch Update 2017-2018
PFAS Untag
Pubmed
Toxline
Literature Search
Pubmed
Toxline
Title and Abstract Screening
Excluded
Not relevant to PECO
Tagged as Supplemental
Exposure assessment or qualitative exposure only
Other PFAS
•
PFOA (335-67-1) and PFOS (1763-23-1)
Literature Search Update (2013-2019)
WOS
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