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Citation
Tags
HERO ID
759772
Reference Type
Journal Article
Title
Alteration of infant attention and activity by polychlorinated biphenyls: Unravelling critical windows of susceptibility using physiologically based pharmacokinetic modeling
Author(s)
Verner, MA; Plusquellec, P; Muckle, G; Ayotte, P; Dewailly, É; Jacobson, SW; Jacobson, JL; Charbonneau, M; Haddad, S
Year
2010
Is Peer Reviewed?
1
Journal
NeuroToxicology
ISSN:
0161-813X
EISSN:
1872-9711
Volume
31
Issue
5
Page Numbers
424-431
Language
English
PMID
20609431
DOI
10.1016/j.neuro.2010.05.011
Web of Science Id
WOS:000281939200002
Relationship(s)
has comment/response
6574116
[Email to Dr. Krista Christensen regarding a request for study details on Verner et al., 2010 ]
Abstract
Pre- and postnatal exposure to polychlorinated biphenyls (PCBs) can impair behavioural function in animal models at doses within the range at which humans are commonly exposed. Yet, epidemiologic studies conducted in the US and Europe are inconsistent with regard to the developmental effects of lactational exposure to these chemicals. This inconsistency may be due to limitations in the current methodological approaches for assessing postnatal exposure to PCBs. Our study used a physiologically based pharmacokinetic (PBPK) model to simulate blood PCB levels during specific pre- and postnatal periods and to evaluate the relation of those levels to infant behaviour. A previously validated PBPK model was used to simulate infant blood PCB-153 levels at delivery and on a month-by-month basis during the first year of life for Inuit infants enrolled in a longitudinal birth cohort. Infant behaviour was assessed using the Behaviour Rating Scales (BRS) of the Bayley Scales of Infant Development (BSID-II) at 11 months of age and video coding of inattention and activity measured during the administration of the mental development subscale of the BSID-II. The estimated pre- and postnatal PCB exposure measures predicted significant increases in inattention and activity at 11 months. Whereas inattention was related to prenatal exposure, activity level, measured by non-elicited activity, was best predicted by postnatal exposure, with the strongest association obtained for simulated PCB levels during the 4th month of life. These findings are consistent with previous reports indicating PCB-induced behavioural alteration in attention and activity level. Simulated infant toxicokinetic profiles for the first year of life revealed windows of susceptibility during which PCBs may impair infant attention and activity.
Keywords
Polychlorinated biphenyls; Behaviour; Infants; Physiologically based pharmacokinetic modeling; Prenatal; Postnatal
Tags
IRIS
•
PCBs
Hazard ID: Epidemiological evidence
ADME and pharmacokinetic modeling
Litsearches
Remaining
LitSearch August 2015
Pubmed
Toxline
WoS
Cited (Nov 2012)
Seed References
•
PCBs Epi Hazard ID
Health Effects
Neurological
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