US EPA

1333333 

Journal Article 

[The effect of phthalate plasticizers on the generative function] 

Aldyreva, MV; Klimova, TS; Izyumova, AS; Timofeevskaia, LA 

1975 

Yes 

Gigiena Truda i Professional'nye Zabolevaniya
ISSN: 0016-9919 

HEEP/76/11364 

12 

12 

25-29 

Russian 

1213487 

BCI:BCI197662028977 

HEEP COPYRIGHT: BIOL ABS. Questions are concerned with the prevalence of phthalates in the human environment and their effect on women occupationally dealing with phthalates; a tendency towards incomplete pregnancy, reduced gestation and delivery rates, increased abortions and prevalence of anovulatory hypoestrogenous cycles is noted. According to toxicometric indicators phthalates, with their chronic action, are referred to as highly toxic and dangerous substances. Introduction of dibutylphthalate (DBP) into the stomach in a dose of 250 mg/kg (Limac) to animals (rats) at the time of implantation (5th and 6th days of gestation) led to an increase in the weight of the embryos and to total embryonal and pre-implantation destruction (30.4 and 18% in experiments as against 19.5 and 11.4% in controls). Introduction of DBP on the 9-11th day of pregnancy resulted in an increase of the fetus weight (except for the 11th day of gestation) and to a reduction in the weight of the placenta by 24.1% by comparison with controls.