Association of serum levels of polychlorinated biphenyls with IL-8 mRNA expression in blood samples from asthmatic and non-asthmatic Japanese children
Tsuji, M; Vogel, CFA; Koriyama, C; Akiba, S; Katoh, T; Kawamoto, T; Matsumura, F
HERO ID
1510368
Reference Type
Journal Article
Year
2012
Language
English
PMID
| HERO ID | 1510368 |
|---|---|
| In Press | No |
| Year | 2012 |
| Title | Association of serum levels of polychlorinated biphenyls with IL-8 mRNA expression in blood samples from asthmatic and non-asthmatic Japanese children |
| Authors | Tsuji, M; Vogel, CFA; Koriyama, C; Akiba, S; Katoh, T; Kawamoto, T; Matsumura, F |
| Journal | Chemosphere |
| Volume | 87 |
| Issue | 11 |
| Page Numbers | 1228-1234 |
| Abstract | <strong>BACKGROUND: </strong>One of the suggested health outcomes of PCB exposure is childhood asthma.<br /><br /><strong>OBJECTIVES: </strong>This study was conducted to find health relevant biomarkers providing the molecular epidemiological evidence for the positive relationship between exposure to PCBs and childhood asthma.<br /><br /><strong>METHODS: </strong>Blood samples from fifteen asthmatic children as well as an equal number of non-asthmatic children (average 2 year old) were collected, and were analyzed for PCBs and their select marker expression by using qRT-PCR.<br /><br /><strong>RESULTS: </strong>Among biomarkers examined IL-8 expression was significantly correlated to serum levels of PCB #163+164 (P=0.022), #170 (P=0.046), #177 (P=0.022), #178 (P=0.022) and #180+193 (P=0.046) in a dose-dependent manner, which was found only among asthmatic children. In contrast, COX-2 correlations to individual congener levels were recognized only among control subjects, not among asthmatic subjects.<br /><br /><strong>CONCLUSION: </strong>Serum concentrations of PCB#163+164, #170, #177, #178 and #180+193 correlate significantly with IL-8 mRNA expressions among asthmatic children. |
| Doi | 10.1016/j.chemosphere.2012.01.022 |
| Pmid | 22326254 |
| Wosid | WOS:000303640200006 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | Young children; PCBs; IL-8; Asthma; AHR |