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Association of serum levels of polychlorinated biphenyls with IL-8 mRNA expression in blood samples from asthmatic and non-asthmatic Japanese children
Tsuji, M; Vogel, CFA; Koriyama, C; Akiba, S; Katoh, T; Kawamoto, T; Matsumura, F
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One of the suggested health outcomes of PCB exposure is childhood asthma.
This study was conducted to find health relevant biomarkers providing the molecular epidemiological evidence for the positive relationship between exposure to PCBs and childhood asthma.
Blood samples from fifteen asthmatic children as well as an equal number of non-asthmatic children (average 2 year old) were collected, and were analyzed for PCBs and their select marker expression by using qRT-PCR.
Among biomarkers examined IL-8 expression was significantly correlated to serum levels of PCB #163+164 (P=0.022), #170 (P=0.046), #177 (P=0.022), #178 (P=0.022) and #180+193 (P=0.046) in a dose-dependent manner, which was found only among asthmatic children. In contrast, COX-2 correlations to individual congener levels were recognized only among control subjects, not among asthmatic subjects.
Serum concentrations of PCB#163+164, #170, #177, #178 and #180+193 correlate significantly with IL-8 mRNA expressions among asthmatic children.
Young children; PCBs; IL-8; Asthma; AHR
Hazard ID: Epidemiological evidence
LitSearch August 2015
Cited (Nov 2012)
PCBs Epi Hazard ID
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