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Citation
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HERO ID
3202670
Reference Type
Journal Article
Title
Urinary toxicokinetics of di-(isononyl)-cyclohexane-1,2-dicarboxylate (DINCH(®)) in humans following single oral administration
Author(s)
Völkel, W; Kiranoglu, M; Dettbarn, G; John, A; Jessel, S; Seidel, A; Fromme, H
Year
2016
Is Peer Reviewed?
Yes
Journal
Toxicology Letters
ISSN:
0378-4274
EISSN:
1879-3169
Publisher
Elsevier
Volume
248
Issue
Elsevier
Page Numbers
16-24
Language
English
PMID
26915627
DOI
10.1016/j.toxlet.2016.02.010
Web of Science Id
WOS:000372433000003
URL
http://
://WOS:000372433000003
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Abstract
Phthalates such as di-2-ethylhexyl phthalate (DEHP) were restricted due to their toxic mainly reprotoxic effects. Therefore compounds such as di-(isononyl)-cyclohexane-1,2-dicarboxylate (DINCH(®)) substitute these phthalates and the exposure of humanes to substitutes may occur. Here, kinetic data are presented to assess the exposure of humans. Male and female volunteers excreted nearly the complete orally administered dose (1mg/kg b.w. corresponding to the tolerable daily intake of EFSA) of di-(isononyl)-cyclohexane-1,2-dicarboxylate within 70h. More than 75% were excreted within 24h. Besides the main metabolite cyclohexane-1,2-dicarboxylic acid (CHDA) quantitated after hydrolysis four further metabolites of DINCH(®) are determined. Cyclohexane-1,2-dicarboxylic acid-mono-(7-hydroxy-4-methyl)octyl ester (OH-MINCH) is the main secondary metabolite with about 14% of the administered dose. Differences in excretion of all metabolites between male and females are small. Based on the generated toxicokinetic data exposure of 20 humans is recalculated from their spot urine sample collected in 2014 and the exposure are clearly below the current tolerable daily intake of 1mg/kg b.w.
Keywords
DINCH (R); Hexamoll (R); Toxicokinetic; Biomonitoring; Exposure
Tags
•
Dibutyl Phthalate (DBP)
Database Searches
Litsearch Jan 2016 - July 2016
Pubmed
Studies with Supporting Data
Toxicokinetics
•
Phthalates – Targeted Search for Epidemiological Studies
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Pubmed
WOS
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Source - Jun 2016 Update (Private)
Pubmed
WOS
Source - Dec 2016 Update (Private)
Pubmed
WOS
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