US EPA

3350228 

Journal Article 

Oxidative stress mediates dibutyl phthalateinduced anxiety-like behavior in Kunming mice 

Yan, B; Guo, J; Liu, X; Li, J; Yang, X; Ma, P; Wu, Y 

2016 

Yes 

Environmental Toxicology and Pharmacology
ISSN: 1382-6689
EISSN: 1872-7077 

45 

45-51 

English 

27262985 

10.1016/j.etap.2016.05.013 

WOS:000381165000007 

http://www.sciencedirect.com/science/article/pii/S1382668916301065
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Among all phthalate esters, dibutyl phthalate (DBP) is only second to di-(2-ethylhexyl) phthalate (DEHP) in terms of adverse health outcomes, and its potential cerebral neurotoxicity has raised concern in recent years. DBP exposure has been reported to be responsible for neurobehavioral effects and related neurological diseases. In this study, we found that neurobehavioral changes induced by DBP may be mediated by oxidative damage in the mouse brain, and that the co-administration of Mangiferin (MAG, 50mg/kg/day) may protect the brain against oxidative damage caused by DBP exposure. The results of ethological analysis (elevated plus maze test and open-field test), histopathological examination of the brain, and assessments of oxidative stress (OS) in the mouse brain showed that there is a link between oxidative stress and anxiety-like behavior produced by DBP at higher doses (25 or 125mg/kg/day). Biomarkers of oxidative stress encompass reactive oxygen species (ROS), glutathione (GSH), malondialdehyde (MDA) and DPC coefficients (DPC). MAG (50mg/kg/day),administered as an antioxidant,can attenuatetheanxiety-like behavior of the tested mice. 

Dibutyl phthalate (DBP); Anxiety-like behavior; Oxidative stress (OS); Mangiferin (MAG)