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HERO ID
3469326
Reference Type
Journal Article
Title
Pregnancy urinary phthalate metabolite concentrations and gestational diabetes risk factors
Author(s)
James-Todd, TM; Meeker, JD; Huang, T; Hauser, R; Ferguson, KK; Rich-Edwards, JW; Mcelrath, TF; Seely, EW
Year
2016
Is Peer Reviewed?
Yes
Journal
Environment International
ISSN:
0160-4120
EISSN:
1873-6750
Publisher
Elsevier Ltd
Location
OXFORD
Volume
96
Page Numbers
118-126
Language
English
PMID
27649471
DOI
10.1016/j.envint.2016.09.009
Web of Science Id
WOS:000386933300014
URL
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84988019716&doi=10.1016%2fj.envint.2016.09.009&partnerID=40&md5=7ccde3ce5b5acbb81d4ff258740f2af3
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Abstract
BACKGROUND:
Epidemiologic studies suggest phthalate metabolite concentrations are associated with type 2 diabetes. GDM is a strong risk factor for type 2 diabetes. Little is known about phthalates and GDM risk factors (i.e. 1st trimester body mass index (BMI), gestational weight gain (GWG), and 2nd trimester glucose levels).
METHODS:
A total of 350 women participating in Lifecodes pregnancy cohort (Boston, MA), delivered at term and had pregnancy urinary phthalate metabolite concentrations. Nine specific gravity-adjusted urinary phthalate metabolites were evaluated. General linear regression was used to assess associations between quartiles of phthalate metabolites and continuous 1st trimester BMI and late 2nd trimester blood glucose. Linear mixed models were used for total GWG. Multivariable logistic regression was used for phthalate concentrations and categorized GWG and impaired glucose tolerance defined as glucose≥140mg/dL based on a 50-gram glucose load test. Models were adjusted for potential confounders.
RESULTS:
There were no associations between 1st trimester urinary phthalate metabolite concentrations and 1st trimester BMI. Mono-ethyl phthalate concentrations averaged across pregnancy were associated with a 2.17 increased odds of excessive GWG (95% CI: 0.98, 4.79). Second trimester mono-ethyl phthalate was associated with increased odds of impaired glucose tolerance (adj. OR: 7.18; 95% CI: 1.97, 26.15). A summary measure of di-2-ethylhexyl phthalate metabolite concentrations were inversely associated with impaired glucose tolerance (adj. OR: 0.25; adj. 95% CI: 0.08, 0.85).
CONCLUSIONS:
Higher exposure to mono-ethyl phthalate, a metabolite of the parent compound of di-ethyl phthalate, may be associated with excessive GWG and impaired glucose tolerance; higher di-2-ethylhexyl phthalate was associated with reduced odds of impaired glucose tolerance.
Keywords
Adult; Blood Glucose; Body Mass Index; Cohort Studies; Diabetes, Gestational/blood/chemically induced/urine; Diethylhexyl Phthalate; Glucose Intolerance/urine; Linear Models; Logistic Models; Phthalic Acids/adverse effects/urine; Pregnancy; Pregnancy Trimester, First/blood/urine; Pregnancy Trimester, Second; Risk Factors; Weight Gain; Body mass index; Gestational diabetes; Gestational weight gain; Impaired glucose tolerance; Phthalates; Pregnancy; 6O7F7IX66E; C42K0PH13C
Tags
IRIS
•
Diethyl phthalate (DEP)
Database searches
Jan 2017 update
Considered new
PubMed
Web of Science
Jan 2020 update
PubMed
Web of Science
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Primary source of health effects
Human health effects studies
•
Phthalates – Targeted Search for Epidemiological Studies
Source – all searches
Pubmed
WOS
Included
DEHP
DBP
DiBP
BBP
DEP
Source - Dec 2016 Update (Private)
Pubmed
WOS
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