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HERO ID
5080506
Reference Type
Journal Article
Title
A transgenerational toxicokinetic model and its use in derivation of Minnesota PFOA water guidance
Author(s)
Goeden, HM; Greene, CW; Jacobus, JA
Year
2019
Is Peer Reviewed?
1
Journal
Journal of Exposure Science & Environmental Epidemiology
ISSN:
1559-0631
EISSN:
1559-064X
Volume
29
Issue
2
Page Numbers
183-195
Language
English
PMID
30631142
DOI
10.1038/s41370-018-0110-5
Web of Science Id
WOS:000459048700006
URL
https://www.proquest.com/docview/2183226047?accountid=171501&bdid=35852&_bd=whuORrgpmRfMfQspw2kmf9pJnTs%3D
Exit
Relationship(s)
has erratum
6320202
Correction:
Abstract
Minnesota has been grappling with extensive per- and polyfluoroalkyl substances (PFASs) groundwater contamination since 2002, in a major metropolitan setting. As toxicological information has accumulated for these substances, the public health community has become increasingly aware of critically sensitive populations. The accumulation of some PFAS in women of childbearing age, and the placental and breastmilk transfer to their offspring, require new risk assessment methods to protect public health. The traditional water guidance paradigm is inadequate to address maternal-to-infant transfer of accumulated levels of perfluorooctanoate (PFOA), in particular. Even short exposures during infancy have dramatic impacts on serum levels for many years. In addition, developmental effects are the critical effects anchoring recent risk assessments. In response, the Minnesota Department of Health created an Excel-based model that incorporates chemical-specific properties and exposure parameters for early life stages. Serum levels were assessed in both formula-fed and breastfed infants, with placental transfer in both scenarios. Peak breastfed infant serum levels were 4.4-fold higher than in formula-fed infants, with both of these scenarios producing serum levels in excess of the adult steady-state level. The development and application of this model to PFOA are described.
Tags
PFAS
•
Additional PFAS (formerly XAgency)
•
PFAS 150
Literature Search Update December 2020
WOS
Literature Search August 2019
Web of Science
Perfluorinated compounds
•
PFBA
Protocol References
•
PFDA
•
PFHxS
•
PFNA
•
PFOA (335-67-1) and PFOS (1763-23-1)
Literature Search Update (2013-2019)
PubMed
WOS
•
PFOA and PFOS OW MCLG Approaches
Cited in White Papers
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