Albumin is the major carrier protein for PFOS, PFOA, PFHxS, PFNA and PFDA in human plasma
Forsthuber, M; Kaiser, AM; Granitzer, S; Hassl, I; Hengstschläger, M; Stangl, H; Gundacker, C
HERO ID
6311640
Reference Type
Journal Article
Year
2020
Language
English
PMID
| HERO ID | 6311640 |
|---|---|
| In Press | No |
| Year | 2020 |
| Title | Albumin is the major carrier protein for PFOS, PFOA, PFHxS, PFNA and PFDA in human plasma |
| Authors | Forsthuber, M; Kaiser, AM; Granitzer, S; Hassl, I; Hengstschläger, M; Stangl, H; Gundacker, C |
| Journal | Environment International |
| Volume | 137 |
| Page Numbers | 105324 |
| Abstract | Perfluoroalkyl (PFAS) substances are widespread in the environment and in organisms. The fact that exposure to PFAS is associated with elevated cholesterol levels is a major concern for human health. Previous investigations, in which bovine serum albumin was frequently studied, indicate that PFOS, PFOA and PFNA bind to serum albumin. However, it is critical to know whether these and other PFAS have a preference for the protein or the lipid fraction in native human blood fractions. For this reason, blood samples from four young healthy volunteers (two women, two men, 23–31 years old) were used for protein size separation and fractionation by the Cohn method in combination with serial ultracentrifugation. The plasma fractions were analyzed for 11 PFAS using high-performance tandem mass spectrometry (HPLC-MS/MS). Although the data are based on a small sample, they clearly show that albumin is the most important carrier protein for PFOS, PFOA, PFHxS, PFNA and PFDA in native human plasma. These five compounds have very little or no affinity for lipoproteins. The confirmation of their transport through albumin is important for the epidemiology of PFAS. The present results must be verified by the examination of a larger number of persons. |
| Doi | 10.1016/j.envint.2019.105324 |
| Pmid | 32109724 |
| Wosid | WOS:000517970800003 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Scopus URL: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079889619&doi=10.1016%2fj.envint.2019.105324&partnerID=40&md5=34782c9fa2595641d7548d6a364348f9 |
| Is Public | Yes |
| Language Text | English |
| Keyword | Albumin; Human plasma; perfluoroalkyl substances (PFAS) |