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Citation
Tags
HERO ID
6505874
Reference Type
Journal Article
Title
Transplacental Transfer of Per- and Polyfluoroalkyl Substances (PFASs): Differences between Preterm and Full-Term Deliveries and Associations with Placental Transporter mRNA Expression
Author(s)
Li, J; Cai, D; Chu, C; Li, QQ; Zhou, Y; Hu, LW; Yang, BY; Dong, GH; Zeng, XW; Chen, D
Year
2020
Is Peer Reviewed?
Yes
Journal
Environmental Science & Technology
ISSN:
0013-936X
EISSN:
1520-5851
Volume
54
Issue
8
Page Numbers
5062-5070
Language
English
PMID
32208722
DOI
10.1021/acs.est.0c00829
Web of Science Id
WOS:000527738300039
Abstract
Previous studies demonstrated that per- and polyfluoroalkyl substances (PFASs) can cross the human placental barrier. However, their transplacental transfer efficiencies (TTEs) have not been investigated in preterm delivery, and the role of placental transport proteins has rarely been explored. Our study hypothesized that the TTEs of PFASs could differ between preterm and full-term deliveries, and some placental transporters could be involved in active maternofetal PFAS transfer. In the present study, the median TTEs of 16 individual PFAS chemicals or isomers were determined to be 0.23 to 1.72 in matched maternal-cord serum pairs with preterm delivery (N = 86), which were significantly lower than those (0.35 to 2.26) determined in full-term delivery (N = 187). Significant associations were determined between the TTEs of several PFASs and the mRNA expression levels of selected transporters located on the brush border membrane. The association patterns also significantly differed between preterm and full-term deliveries and exhibited a chemical-specific manner. For example, the expression of MRP2 exhibited significantly positive associations with the TTEs of linear and branched perfluorooctanesulfonic acid (PFOS) isomers in full-term delivery, but negative, nonsignificant associations were observed in preterm delivery. This is the first study to compare the transplacental transfer of PFASs between preterm and full-term deliveries and indicate that some placental transport proteins could be involved in active transmission. The mechanisms underlying the cross-placental transfer of PFASs require further investigations to better elucidate their risks to fetal health and birth outcomes.
Tags
NAAQS
•
LitSearch-NOx (2024)
Forward Citation Search
Epidemiology
Results
Reproductive
PubMed
WoS
PFAS
•
Expanded PFAS SEM (formerly PFAS 430)
Litsearch Update: November 2021
Web of Science
Perfluorooctane
•
PFAS 150
Literature Search Update December 2021
WOS
Missing 2021 searches
Literature Search Update December 2020
WOS
Literature Search August 2019
Web of Science
Screened Studies
Supplemental
Perfluorinated compounds
Perfluorooctane
•
PFBA
Literature Search Update 4/2022
June 2022 Pelch Database
•
PFDA
June 2022 Pelch Database
Submitted to EPA
Literature Searches (through April 2023 update and post-public comment/peer review)a
Other
Published PFAS SEMs
Title & Abstract Screening
Tagged as Supplemental
Full Text Screening
In vivo MOA, including non-PECO exposure route
ADME
•
PFHxA
Results pulled from Pelch database May 2022
HAWC
•
PFHxS
Database searches
Pelch PFAS SEM
Inclusion
TiAb
Supplemental
Full Text
•
PFNA
June 2022 Pelch Database
•
PFOA (335-67-1) and PFOS (1763-23-1)
LitSearch: Feb 2019 - May 2020
PubMed
WoS
Literature Search Update (Apr 2019 - Sep 2020)
PubMed
WOS
•
PFOA and PFOS OW MCLG Approaches
Cited in White Papers
•
Yale PFAS Liver study
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