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Tags
HERO ID
6553457
Reference Type
Technical Report
Subtype
EPA Report
Title
Integrated science assessment (ISA) for oxides of nitrogen: Health criteria (Final report, Jan 2016)
Author(s)
U.S. Environmental Protection Agency :: U.S. EPA
Year
2016
Is Peer Reviewed?
Yes
Publisher
U.S. Environmental Protection Agency
Location
Washington, DC
Report Number
EPA/600/R-15/068
Number of Pages
1148
Language
English
URL
https://cfpub.epa.gov/ncea/isa/recordisplay.cfm?deid=310879
Relationship(s)
is supplemented by
1988303
Supplemental table S1-1. Epidemiologic studies of health effects not evaluated in the ISA for oxides for nitrogen
Abstract
This final report provides the U.S. EPA’s evaluation and synthesis of the most policy-relevant science related to the health effects of gaseous oxides of nitrogen. It provides a critical part of the scientific foundation for the U.S. EPA’s decision regarding the adequacy of the current primary (health-based) national ambient air quality standards for nitrogen dioxide.
Oxides of nitrogen are one of six principal (or criteria) pollutants for which the U.S. EPA has established national ambient air quality standards (NAAQS). For gaseous oxides of nitrogen, the NAAQS are specified in terms of nitrogen dioxide (NO2). The Clean Air Act requires the U.S. EPA to periodically review the scientific basis for these standards by preparing an ISA. These reviews play a significant role in the U.S. EPA’s commitment to ensuring a clean and healthy environment for the public. The Clear Air Scientific Advisory Committee, an independent panel of scientific experts mandated by Section 109(d) of the Clean Air Act, is charged with independent scientific review of the U.S. EPA’s air quality criteria.
This report is part of the Agency’s periodic review of the primary (health-based) NAAQS for NO2. Overall, findings integrated from previous and recent studies strengthen the conclusions from the previous NAAQS review, which was completed in 2010. The cumulative body of evidence indicates that short-term exposure to NO2 can cause respiratory effects, in particular, effects related to asthma exacerbation. Recent results also strengthen the evidence that the respiratory effects of short-term NO2 exposure are independent of the effects of many other traffic-related pollutants. There is now stronger evidence for a relationship between long-term exposure to NO2 and respiratory effects, particularly the development of asthma in children. Results suggest that short-term exposure to NO2 may be associated with cardiovascular effects and premature mortality and that long-term exposure may be associated with cardiovascular effects, diabetes, poorer birth outcomes, premature mortality, and cancer; however, it is uncertain whether NO2 exposure has an effect on these health outcomes that is independent from the effects of other traffic-related pollutants.
Tags
•
ISA - Lead (2024 Final Project Page)
Included in External Review Draft
Appendix 12 (Process)
Integrated Synthesis
Included in Final Draft
Appendix 12 (Process)
Integrated Synthesis
•
ISA-NOx (2016)
•
ISA NOxSOxPM Ecology (2018)
Cited in First Draft
Chapter 1
Chapter 2
Chapter 3
Cited in the Second Draft
Chapter 1
Appendix 2
Appendix 3
•
ISA NOxSOxPM Ecology (2020- Final Project Page)
Cited
Executive Summary
Integrated Synthesis
Appendix 2
Appendix 3
•
ISA-Ozone (2020 Final Project Page)
Full-Text Screening Included
References from Other Sources
Included in ISA First Draft
Integrated Synthesis
Appendix 1
Appendix 3
Appendix 10
Included in ISA Final Draft
Integrated Synthesis
Appendix 1
Appendix 3
Appendix 10
•
ISA-PM (2019)
Peer Input Draft
Chapter 3
Chapter 6
1st Draft
Chapter 3
Chapter 11
Final ISA
Chapter 3
Chapter 11
•
ISA-SOx
Cited Second ERD Dec2016
Cited in Final ISA Dec2017
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