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Citation
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HERO ID
6572032
Reference Type
Technical Report
Title
11th Report on Carcinogens: Bromodichloromethane
Author(s)
National Toxicology Program :: NTP
Year
2004
Publisher
National Toxicology Program
Location
Research Triangle Park, NC
Page Numbers
III35-III36
Language
English
URL
https://ntrl.ntis.gov/NTRL/dashboard/searchResults/titleDetail/PB2005104914.xhtml
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Relationship(s)
is a chapter of
093207
11th Report on carcinogens
Abstract
Bromodichloromethane is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity in experimental animals (NTP 1987, IARC 1991, 1999). When administered by gavage, bromodichloromethane increased the incidences of tubular cell adenomas and adenocarcinomas in the kidney, and adenocarcinomas and adenomatous polyps in the large intestine in rats of both sexes. When administered by gavage, bromodichloromethane increased the incidences of tubular cell adenomas and adenocarcinomas in the kidney of male mice, and increased the incidences of hepatocellular adenomas and carcinomas in female mice (NTP 1987, ATSDR 1989).
No data were available to evaluate the carcinogenic effects in humans following long-term oral exposure to bromodichloromethane per se (IARC 1999). Several epidemiological studies indicate there may be an association between ingestion of chlorinated drinking water (which typically contains bromodichloromethane) and increased risk of cancer in humans, but these studies cannot provide information on whether any observed effects are due to bromodichloromethane or to one or more of the hundreds of other by-products that are also present in chlorinated water (ATSDR 1989).
Tags
•
Biphenyl
Considered
Excluded References
•
Chloroprene
Cited 2010 Final
•
Hexachloroethane (HCE) (Final, 2011)
•
Tetrachloroethylene (Perc) (Final, 2012)
Hazard
Respiratory
•
Trichloroethylene (TCE) (Final, 2011)
NAAQS
•
ISA-NOx (2016)
2008 Final
OPPT REs
•
OPPT_Perchloroethylene (Perc)_C. Engineering
Total – title/abstract screening
Off topic
•
OPPT_Perchloroethylene (Perc)_D. Exposure
Total – title/abstract screening
Off topic
•
OPPT_Perchloroethylene (Perc)_E. Fate
Total – title/abstract screening
Off topic
•
OPPT_Perchloroethylene (Perc)_F. Human Health
Total – title/abstract screening
Off topic
•
Nanoscale Carbon
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