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6572032 
Technical Report 
11th Report on Carcinogens: Bromodichloromethane 
National Toxicology Program :: NTP 
2004 
National Toxicology Program 
Research Triangle Park, NC 
III35-III36 
English 
is a chapter of 093207 11th Report on carcinogens
Bromodichloromethane is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity in experimental animals (NTP 1987, IARC 1991, 1999). When administered by gavage, bromodichloromethane increased the incidences of tubular cell adenomas and adenocarcinomas in the kidney, and adenocarcinomas and adenomatous polyps in the large intestine in rats of both sexes. When administered by gavage, bromodichloromethane increased the incidences of tubular cell adenomas and adenocarcinomas in the kidney of male mice, and increased the incidences of hepatocellular adenomas and carcinomas in female mice (NTP 1987, ATSDR 1989).

No data were available to evaluate the carcinogenic effects in humans following long-term oral exposure to bromodichloromethane per se (IARC 1999). Several epidemiological studies indicate there may be an association between ingestion of chlorinated drinking water (which typically contains bromodichloromethane) and increased risk of cancer in humans, but these studies cannot provide information on whether any observed effects are due to bromodichloromethane or to one or more of the hundreds of other by-products that are also present in chlorinated water (ATSDR 1989).