Health & Environmental Research Online (HERO)


Print Feedback Export to File
1341706 
Journal Article 
Potentiometric flow injection analysis of drotaverine hydrochloride in pharmaceutical preparations 
Ibrahim, H; Issa, YM; Abu-Shawish, HM 
2005 
Yes 
Analytical Letters
ISSN: 0003-2719
EISSN: 1532-236X 
38 
1 
111-132 
English 
WOS:000226780100009 
Five poly (vinyl chloride) (PVC) membrane electrodes for the determination of drotaverine hydrochloride (DvCl) were constructed and fully characterized in terms of composition, life span, response time, usable pH range, working concentration range, and temperature. The membranes of these electrodes consist of drotaverinium-silicotungstate (Dv-ST), silicomolybdate (Dv-SM), phosphotungstate (Dv-PT), phosphomolybdate (Dv-PM), or tetraphenylborate (Dv-TPB) ion associations dispersed in PVC matrix with dibutyl phthalate plasticizer. The electrodes showed near-Nernstian response over the concentration range of 2.0 x 10(-6) to 1.0 X 10(-2) M DvCl and were applied to the potentiometric determination of drotaverinium ion in pharmaceutical preparations in steady-state and flow injection (FI) conditions with average recoveries of 98.1-102.2% and relative standard deviation of 0.308-1.310%. The electrodes exhibit good selectivity for DvCl with respect to a large number of inorganic cations, organic cations, sugars, and amino acids. The sensitivities of these electrodes are high enough to measure as low as 0.87 mug/mL of DvCl which permits the determination of the K-sp values of the ion associates used. 
drotaverine hydrochloride; ion-selective electrode; ion exchanger; flow injection analysis; urine; PVC membrane