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Citation
Tags
HERO ID
1519035
Reference Type
Journal Article
Title
Proteomic approach of adaptive response to arsenic stress in Exiguobacterium sp. S17, an extremophile strain isolated from a high-altitude Andean Lake stromatolite
Author(s)
Belfiore, C; Ordoñez, OF; Farías, ME
Year
2013
Is Peer Reviewed?
Yes
Journal
Extremophiles
ISSN:
1431-0651
EISSN:
1433-4909
Volume
17
Issue
3
Page Numbers
421-431
Language
English
PMID
23525943
DOI
10.1007/s00792-013-0523-y
Web of Science Id
WOS:000318169900006
Abstract
The North-Western part of Argentina is particularly rich in wetlands located in the Puna in an altitude between 3,600 and 4,600 m above sea level. Most of these high-altitude Andean lakes are inhospitable areas due to extreme habitat conditions such as high contents of toxic elements, particularly arsenic. Exiguobacterium sp. S17, isolated from stromatolites in Laguna Socompa, exhibited remarkable tolerance to high arsenic concentration, i.e., it tolerated arsenic concentration such as 10 mM of As(III) and 150 mM of As(V). A proteomics approach was conducted to reveal the mechanisms that provide the observed outstanding resistance of Exiguobacterium sp. S17 against arsenic. A comparative analysis of S17, exposed and unexposed to arsenic revealed 25 differentially expressed proteins. Identification of these proteins was performed by MALDI-TOF/MS revealing upregulation of proteins involved in energy metabolism, stress, transport, and in protein synthesis being expressed under arsenic stress. To our knowledge, this work represents the first proteomic study of arsenic tolerance in an Exiguobacterium strain.
Keywords
Exiguobacterium; Arsenic stress; Proteomics; Extreme environment
Tags
IRIS
•
Arsenic Hazard ID
ToxNet
PubMed
Considered New
PubMed
Considered New
PubMed
ToxNet
Excluded
Toxnet Duplicates
WOS
ToxNet
Excluded
Toxnet Duplicates
ToxNet
Excluded
Toxnet Duplicates
ToxNet
Excluded
Toxnet Duplicates
ToxNet
Excluded
Toxnet Duplicates
WOS
ToxNet
Excluded
Toxnet Duplicates
ToxNet
Excluded
Toxnet Duplicates
ToxNet
Excluded
Toxnet Duplicates
2. Lit Search Updates through Oct 2015
PubMed
WOS
ToxNet
Considered
7. Other Studies through Oct 2015
Other
•
Arsenic (Inorganic)
1. Literature
Lit search updates through Oct 2015
3. Hazard ID Screening
Other potentially supporting studies
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