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Citation
Tags
HERO ID
1519049
Reference Type
Journal Article
Subtype
Review
Title
Molecular features in arsenic-induced lung tumors
Author(s)
Hubaux, R; Becker-Santos, DD; Enfield, KSS; Rowbotham, D; Lam, S; Lam, WL; Martinez, VD
Year
2013
Is Peer Reviewed?
1
Journal
Molecular Cancer
ISSN:
1476-4598
Volume
12
Page Numbers
20
Language
English
PMID
23510327
DOI
10.1186/1476-4598-12-20
Web of Science Id
WOS:000317832300001
Abstract
Arsenic is a well-known human carcinogen, which potentially affects ~160 million people worldwide via exposure to unsafe levels in drinking water. Lungs are one of the main target organs for arsenic-related carcinogenesis. These tumors exhibit particular features, such as squamous cell-type specificity and high incidence among never smokers. Arsenic-induced malignant transformation is mainly related to the biotransformation process intended for the metabolic clearing of the carcinogen, which results in specific genetic and epigenetic alterations that ultimately affect key pathways in lung carcinogenesis. Based on this, lung tumors induced by arsenic exposure could be considered an additional subtype of lung cancer, especially in the case of never-smokers, where arsenic is a known etiological agent. In this article, we review the current knowledge on the various mechanisms of arsenic carcinogenicity and the specific roles of this metalloid in signaling pathways leading to lung cancer.
Keywords
Arsenic; Arsenite; Lung cancer; Epigenetic; Reactive oxygen species; Epidermal growth factor receptor; Phosphatidylinositol 3-kinases; NFE2-related factor 2
Tags
IRIS
•
Arsenic Hazard ID
ToxNet
Excluded
Non Peer Reviewed
PubMed
Excluded
Non Peer Reviewed
WOS
ToxNet
Excluded
Non Peer Reviewed
Toxnet Duplicates
ToxNet
Excluded
Non Peer Reviewed
Reviews
Toxnet Duplicates
ToxNet
Excluded
Non Peer Reviewed
Reviews
Toxnet Duplicates
ToxNet
Excluded
Non Peer Reviewed
Reviews
Toxnet Duplicates
ToxNet
Excluded
Reviews
Toxnet Duplicates
ToxNet
Excluded
Non Peer Reviewed
Reviews
Toxnet Duplicates
ToxNet
Excluded
Non Peer Reviewed
Reviews
Toxnet Duplicates
ToxNet
Excluded
Non Peer Reviewed
Reviews
Toxnet Duplicates
2. Lit Search Updates through Oct 2015
PubMed
WOS
ToxNet
Initial Filter
Non Peer Reviewed
Reviews
7. Other Studies through Oct 2015
Review/Risk Assessment/Guidance document
•
Arsenic (Inorganic)
1. Literature
Lit search updates through Oct 2015
2. Initial Filter
Reviews
Cited in Volume 1
•
Arsenic Susceptibility
Life Stages Citation Mapping
20%-25%
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