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Journal Article 
Air pollution and congenital heart defects 
Agay-Shay, K; Friger, M; Linn, S; Peled, A; Amitai, Y; Peretz, C 
Environmental Research
ISSN: 0013-9351
EISSN: 1096-0953 
Environmental factors such as ambient air pollution have been associated with congenital heart defects. The aim of this study was to investigate the association between gestational exposure to air pollution and the risk of congenital heart defects. We conducted a registry-based cohort study with a total of 135,527 live- and still-births in the Tel-Aviv region during 2000-2006. We used a Geographic Information System-based spatiotemporal approach with weekly inverse distance weighting modeling to evaluate associations between gestational exposure to ambient air pollution during weeks 3-8 of pregnancy and the risk for congenital heart defects. The following pollutants were studied: carbon monoxide, nitrogen-dioxide, ozone, sulfur-dioxide and particulate matter with aerodynamic diameter smaller than 10μm and 2.5μm (PM10, PM2.5 respectively). Logistic models, adjusted for socio-demographic covariates were used to evaluate the associations. We found that maternal exposure to increased concentrations of PM10 was associated with multiple congenital heart defects (adjusted OR 1.05, 95% CI: 1.01 to 1.10 for 10μg/m(3) increment). An inverse association was observed between concentrations of PM2.5 and isolated patent ductus arteriosus (adjusted OR 0.78, 95% CI: 0.68 to 0.91 for 5µg/m(3) increment). Sensitivity analyses showed that results were consistent. Generally there were no evidence for an association between gaseous air pollutants and congenital heart defects.Our results for PM10 and congenital heart defects confirm results from previous studies. The results for PM2.5 need further investigations. 
Congenital heart defects; Congenital malformations; Birth defects; Congenital anomalies; Air pollution 
          Final Cited
• ISA-Ozone (2020 Final Project Page)
     Literature Search Results
     Literature Search - Included
          Keyword Search
               Topic Classified Epidemiology
     Title-Abstract Screening (SWIFT-AS) - Included
          Title-Abstract Screening (SWIFT-AS) - Included
     Full-Text Screening Included
          Full-Text Screening Included
     Included in ISA First Draft
          Appendix 7
     Included in ISA Final Draft
          Appendix 7
• ISA-PM (2019)
     Peer Input Draft
          Chapter 6
     1st Draft
          Chapter 9
     Final ISA
          Chapter 9
     Health Effects
     Chapter Review
          Health Effects
     Cited in First ERD Nov2015
     Cited Second ERD Dec2016
     Cited in Final ISA Dec2017
          Chapter 5 – Health