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3859051 
Journal Article 
Characterization of estrogenic and androgenic activity of phthalates by the XenoScreen YES/YAS in vitro assay 
Czernych, R; Chraniuk, M; Zagożdżon, P; Wolska, L 
2017 
Yes 
Environmental Toxicology and Pharmacology
ISSN: 1382-6689
EISSN: 1872-7077 
53 
95-104 
English 
The presented study investigates and compares the estrogenic and androgenic activities of commonly used diesters of phthalic acid (phthalates) using the XenoScreen YES/YAS assay. Phthalates are commonly used plasticizers in polymers dedicated for i.e. food and drug containers. Since phthalates are not chemically bonded to the polymer, they can leach or migrate from the polymer. Therefore, phthalates are identified as contaminants in a variety of consumer products. Investigation of estrogenic and androgenic activities of phthalates (DEP, DBP, BBP, DEHP and DINP) showed no significant effect of tested substances either on hERα or hAR receptors. Phthalates exhibited strong anti-estrogenic (IC50 for BBP=8.66μM, IC50 for DEHP=3.61μM and IC50 for DINP=0.065μM) and anti-androgenic (IC50 for BBP=5.30μM, IC50 for DEHP=2.87μM and IC50 for DINP=0.068μM) activities. 
IRIS
• BBP (Butyl benzyl phthalate)
     Literature Search
          Literature Search: February 2017 - July 2017
               Pubmed
• Dibutyl Phthalate (DBP)
     Database Searches
          LitSearch Jan 2017 - July 2017
               Pubmed
• Diethyl phthalate (DEP)
     Database searches
          Literature Search: Jan 2017-July 2017
               PubMed
     Excluded: No Primary Data on Health Effects
          Use in sample prep or assay
• Diisononyl Phthalate (DINP)
     Literature Search
          LitSearch Jan 2017 - July 2017 Update
               Considered new
               PubMed
               Toxline
• Phthalates – Targeted Search for Epidemiological Studies
     Excluded
     Source - August 2017 Update (Private)
          WOS - Forward Search Results
     Source - August 2018 Update
          WOS
          Level 1 Screen - Title & Abstract
               Excluded