Characterization of estrogenic and androgenic activity of phthalates by the XenoScreen YES/YAS in vitro assay | Health & Environmental Research Online (HERO)

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Citation
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HERO ID

3859051

Reference Type

Journal Article

Title

Characterization of estrogenic and androgenic activity of phthalates by the XenoScreen YES/YAS in vitro assay

Author(s)

Czernych, R; Chraniuk, M; Zagożdżon, P; Wolska, L

Year

2017

Is Peer Reviewed?

Yes

Journal

Environmental Toxicology and Pharmacology
ISSN: 1382-6689
EISSN: 1872-7077

Publisher

Elsevier

Location

AMSTERDAM

Volume

Issue

Elsevier

Page Numbers

95-104

Language

English

PMID

28528305

DOI

10.1016/j.etap.2017.05.010

Web of Science Id

WOS:000406566200013

URL

https://linkinghub.elsevier.com/retrieve/pii/S138266891730131X
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Abstract

The presented study investigates and compares the estrogenic and androgenic activities of commonly used diesters of phthalic acid (phthalates) using the XenoScreen YES/YAS assay. Phthalates are commonly used plasticizers in polymers dedicated for i.e. food and drug containers. Since phthalates are not chemically bonded to the polymer, they can leach or migrate from the polymer. Therefore, phthalates are identified as contaminants in a variety of consumer products. Investigation of estrogenic and androgenic activities of phthalates (DEP, DBP, BBP, DEHP and DINP) showed no significant effect of tested substances either on hERα or hAR receptors. Phthalates exhibited strong anti-estrogenic (IC50 for BBP=8.66μM, IC50 for DEHP=3.61μM and IC50 for DINP=0.065μM) and anti-androgenic (IC50 for BBP=5.30μM, IC50 for DEHP=2.87μM and IC50 for DINP=0.068μM) activities.

Keywords

Endocrine disrupting chemicals; Phthalates; Yeast test; Androgenic potential; Estrogenic potential

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