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3859065 
Journal Article 
Exposure Marker Discovery of Phthalates Using Mass Spectrometry 
Hsu, JY; Shih, CL; Liao, PC 
2017 
Yes 
Spec Iss 
S0062 
English 
Phthalates are chemicals widely used in industry and the consequences on human health caused by exposure to these agents are of significant interest currently. The urinary metabolites of phthalates can be measured and used as exposure markers for the assessment of the actual internal contamination of phthalates coming from different sources and absorbed by various ways. The purpose of this paper is to review the markers for exposure and risk assessment of phthalates such as di-methyl phthalate (DMP), di-ethyl phthalate (DEP), di-butyl phthalate (DBP), benzylbutyl phthalate (BBP), di-(2-ethylhexyl)phthalate (DEHP), di-(2-propylheptyl)phthalate (DPHP), di-iso-nonyl phthalate (DINP), di-n-octyl phthalate (DnOP) and di-iso-decyl phthalate (DIDP), and introduction of the analytical approach of three metabolomics data processing approaches that can be used for chemical exposure marker discovery in urine with high-resolution mass spectrometry (HRMS) data. 
biomonitoring; metabolomics; phthalates 
IRIS
• BBP (Butyl benzyl phthalate)
     Literature Search
          Literature Search: February 2017 - July 2017
               Pubmed
• Dibutyl Phthalate (DBP)
     Database Searches
          LitSearch Jan 2017 - July 2017
               Pubmed
• Diethyl phthalate (DEP)
     Database searches
          Literature Search: Jan 2017-July 2017
               PubMed
     Excluded: No Primary Data on Health Effects
          Measurement methods
• Diisononyl Phthalate (DINP)
     Literature Search
          LitSearch Jan 2017 - July 2017 Update
               Considered new
               PubMed
• Phthalates – Targeted Search for Epidemiological Studies
     Source – all searches
          Pubmed
     Excluded
     Source - August 2017 Update (Private)
          Pubmed