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HERO ID
3861413
Reference Type
Journal Article
Title
Comparative toxicity and endocrine disruption potential of urban and rural atmospheric organic PM1 in JEG-3 human placental cells
Author(s)
van Drooge, BL; Marqueño, A; Grimalt, JO; Fernández, P; Porte, C
Year
2017
Is Peer Reviewed?
Yes
Journal
Environmental Pollution
ISSN:
0269-7491
EISSN:
1873-6424
Publisher
Elsevier Ltd
Location
OXFORD
Volume
230
Page Numbers
378-386
Language
English
PMID
28672150
DOI
10.1016/j.envpol.2017.06.025
Web of Science Id
WOS:000412250900040
Abstract
Outdoor ambient air particulate matter and air pollution are related to adverse effects on human health. The present study assesses the cytotoxicity and ability to disrupt aromatase activity of organic PM1 extracts from rural and urban areas at equivalent air volumes from 2 to 30 m(3), in human placental JEG-3 cells. Samples were chemically analyzed for particle bounded organic compounds with endocrine disrupting potential, i.e. PAH, O-PAH, phthalate esters, but also for organic molecular tracer compounds for the emission source identification. Rural samples collected in winter were cytotoxic at the highest concentration tested and strongly inhibited aromatase activity in JEG-3 cells. No cytotoxicity was detected in summer samples from the rural site and the urban samples, while aromatase activity was moderately inhibited in these samples. In the urban area, the street site samples, collected close to intensive traffic, showed stronger inhibition of aromatase activity than the samples simultaneously collected at a roof site, 50 m above ground level. The cytotoxicity and endocrine disruption potential of the samples were linked to combustion products, i.e. PAH and O-PAH, especially from biomass burning in the rural site in winter.
Keywords
PM1; organic air pollution; biomass burning; human placental JEG 3 cells; cytotoxicity; endocrine disruption
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IRIS
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Dibutyl Phthalate (DBP)
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