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3981238 
Journal Article 
Review 
Global distribution of perfluorochemicals (PFCs) in potential human exposure source-A review 
Jian, JM; Guo, Y; Zeng, L; Liang-Ying, L; Lu, X; Wang, F; Zeng, EY 
2017 
Environment International
ISSN: 0160-4120
EISSN: 1873-6750 
PERGAMON-ELSEVIER SCIENCE LTD 
OXFORD 
108 
51-62 
English 
Human exposure to perfluorochemicals (PFCs) has attracted mounting attention due to their potential harmful effects. Breathing, dietary intake, and drinking are believed to be the main routes for PFC entering into human body. Thus, we profiled PFC compositions and concentrations in indoor air and dust, food, and drinking water with detailed analysis of literature data published after 2010. Concentrations of PFCs in air and dust samples collected from home, office, and vehicle were outlined. The results showed that neutral PFCs (e.g., fluorotelomer alcohols (FTOHs) and perfluorooctane sulfonamide ethanols (FOSEs)) should be given attention in addition to PFOS and PFOA. We summarized PFC concentrations in various food items, including vegetables, dairy products, beverages, eggs, meat products, fish, and shellfish. We showed that humans are subject to the dietary PFC exposure mostly through fish and shellfish consumption. Concentrations of PFCs in different drinking water samples collected from various countries were analyzed. Well water and tap water contained relatively higher PFC concentrations than other types of drinking water. Furthermore, PFC contamination in drinking water was influenced by the techniques for drinking water treatment and bottle-originating pollution. 
Drinking water; Exposure; Indoor air; Perfluorochemical 
PFAS
• Additional PFAS (formerly XAgency)
     Literature Search November 2019
          Other Sources
               Reference list review of included studies
     Screened Studies
          Supplemental
• Expanded PFAS SEM (formerly PFAS 430)
     Litsearch: September 2019
          PubMed
          Web of Science
     Screened Studies
          Supplemental
     Perfluorooctane
• ^Per- and Polyfluoroalkyl Substances (PFAS)
     PFOA (335-67-1) and PFOS (1763-23-1)
          Literature Search – Adverse outcome pathway (2015-present)
               Pubmed
• PFAS 150
     Literature Search Update December 2020
          PubMed
          WOS
     Literature Search August 2019
          PubMed
          Web of Science
     Not prioritized for screening
     Perfluorooctane
     Perfluorooctanesulfonic acid
• PFAS Universe
     Data Source
          Web of Science
          Pubmed
     Perfluorooctane
     Perfluorooctanesulfonate
     Perfluorooctanesulfonic acid
     Perfluorooctanoate
     Perfluorooctanoic acid
• PFNA
     Litsearch Update 2017-2018
          Exclusions
               Reviews
          Toxline
     Litsearch Addl Synonyms 2018
          Exclusions
               Reviews
     Literature Search
          Exclusions
               Reviews
          Toxline
• PFOSA
     Literature Search
          Pubmed
     Screening Results
          Excluded/Not on Topic
OW - HHRAB
• PFOA (335-67-1) and PFOS (1763-23-1)
     Literature Search – Adverse outcome pathway (2015-present)
          Pubmed
     Screening Results
          Excluded/Not on Topic
     Literature Search Update (2013-2019)
          PubMed
          WOS