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6315698 
Journal Article 
Incidence of ocular conditions associated with perfluoroalkyl substances exposure: Isomers of C8 Health Project in China 
Zeeshan, M; Yang, Y; Zhou, Y; Huang, W; Wang, Z; Zeng, XY; Liu, RQ; Yang, BY; Hu, LW; Zeng, XW; Sun, X; Yu, Y; Dong, GH 
2020 
Environment International
ISSN: 0160-4120
EISSN: 1873-6750 
137 
105555 
English 
The detrimental effects of perfluoroalkyl substances (PFASs) on several physiological systems have been reported, but the association of PFASs with eye, one of the most sensitive and exposed organ, has never been explored. To investigate the association between eye diseases including visual impairment (VI) and PFASs isomers, a cross-sectional stratified study was conducted in 1202 Chinese population, aged 22-96 years, from Shenyang, China. A standard protocol including Snellen vision chart, slit-lamp microscopy and direct ophthalmoscopy was used to examine eye diseases/conditions relating to anterior and posterior segment of eyes. In addition, we measured the blood concentrations of 19 linear and branched PFASs at one-time point. Results indicated that blood levels of PFASs were significantly higher in eye disease group than normal group. PFASs exposure were positively associated with both combined eye diseases and individual eye diseases. Among other PFASs, linear perfluorooctane sulfonate (n-PFOS; odds ratio [OR] = 3.37, 95% confidence interval [CI]: 2.50, 4.56), branched perfluorooctane sulfonate (Br-PFOS; OR = 2.25, 95% CI: 1.72, 2.93) and linear perfluorooctanoic acid (n-PFOA; OR = 1.79, 95% CI: 1.36, 2.37) significantly increases the odds of VI. Vitreous disorder was adversely associated with long-chain PFASs exposure. For example, perfluorotridecanoic acid (PFTrDA; OR = 1.86, 95% CI: 1.51, 2.29) and perfluorodecanoic acid (PFDA; OR = 1.79, 95% CI: 1.36, 2.36) showed the most significant association. In conclusion, this study suggests higher serum PFASs levels were associated with increase odds of VI and vitreous disorder in Chinese adults. 
Perfluoroalkyl substances (PFASs); PFASs isomers; Eye diseases; Visual impairment; Vitreous disorder 
PFAS
• Additional PFAS (formerly XAgency)
• Expanded PFAS SEM (formerly PFAS 430)
     Litsearch Update: November 2021
          PubMed
          Web of Science
     Perfluorooctane
• PFAS 150
     Literature Search Update December 2021
          PubMed
          WOS
     Missing 2021 searches
     Literature Search Update December 2020
          PubMed
          WOS
     Literature Search August 2019
          PubMed
          Web of Science
          Other sources
               Reference list review of included studies
     Screened Studies
          Included
               Include (TIAB)
               Include (Full Text)
     Perfluorinated compounds
     Perfluorooctane
     Perfluorooctanesulfonate
     Perfluorotridecanoic acid
• PFAS Universe
     Data Source
          Web of Science
          Pubmed
          Screened Studies
               Included
                    Include (TIAB)
               Excluded
                    Exclude (Full Text)
     Perfluorodecanoate
     Perfluorodecanoic acid
     Perfluorooctane
     Perfluorooctanesulfonate
     Perfluorooctanesulfonic acid
     Perfluorooctanoate
     Perfluorotridecanoate
     Perfluorotridecanoic acid
     Perfluorooctanoic acid
• PFBA
     Literature Search Update 4/2022
     June 2022 Pelch Database
• PFDA
     Literature Search
          Pubmed
          WOS
          Other
               Published PFAS SEMs
     Literature Search Update 5/2020
          PubMed
     Literature Search Update 4/2021
          PubMed
          WoS
     Scopus: April 2021
     June 2022 Pelch Database
     Literature Searches (through April 2023 update and post-public comment/peer review)
          Title & Abstract Screening
               Full Text Screening
                    Studies Meeting PECO
                         Human health effects studies
• PFHxA
     Results pulled from Pelch database May 2022
     HAWC
• PFHxS
     Database searches
          Pelch PFAS SEM
     Inclusion
          TiAb
          Full Text
               Human Study
• PFNA
     Title and Abstract Screening
          Full Text Screening
               Studies Meeting PECO
                    Human health effects studies
     June 2022 Pelch Database
OW - HHRAB
• PFOA (335-67-1) and PFOS (1763-23-1)
     LitSearch: Feb 2019 - May 2020
          PubMed
          WoS
     Literature Search Update (Apr 2019 - Sep 2020)
          PubMed
          WOS
• PFOA and PFOS OW MCLG Approaches
     Cited in White Papers