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2720217 
Journal Article 
Polyfluoroalkyl chemicals in pooled blood serum from infants, children, and adults in Australia 
Toms, LML; Calafat, AM; Kato, K; Thompson, J; Harden, F; Hobson, P; Sjödin, A; Mueller, JF 
2009 
Yes 
Environmental Science and Technology
ISSN: 0013-936X
EISSN: 1520-5851 
43 
11 
4194-4199 
English 
Polyfluoroalkyl chemicals (PFCs) have been used worldwide for more than 50 years in a wide variety of industrial and consumer products. Limited data exist on human exposure to PFCs in the Southern Hemisphere. Human blood serum collected in southeast Queensland, Australia, in 2006−2007 from 2420 donors was pooled according to age (cord blood, 0−0.5, 0.6−1, 1.1−1.5, 1.6−2, 2.1−2.5, 2.6−3, 3.1−3.5, 3.6−4, 4.1−6, 6.1−9, 9.1−12, 12.1−15, 16−30, 31−45, 46−60, and >60 years) and gender and was analyzed for eight PFCs. Across all pools, perfluorooctane sulfonate (PFOS) was detected at the highest mean concentration (15.2 ng/mL) followed by perfluorooctanoate (PFOA, 6.4 ng/mL), perfluorohexane sulfonate (PFHxS, 3.1 ng/mL), perfluorononanoate (PFNA, 0.8 ng/mL), 2-(N-methyl-perfluorooctance sulfonamide) acetate (Me-PFOSA-AcOH, 0.66 ng/mL), and perfluorodecanoate (PFDeA, 0.29 ng/mL). Perfluorooctane sulfonamide was detected in only 24% of the pools, and 2-(N-ethylperfluorooctane sulfonamide) acetate was detected in only one. PFOS concentrations were significantly higher in pools from adult males than from adult females (p = 0.002); no gender differences were apparent in the pools from children (<12 years old). The highest mean concentrations of PFOA, PFHxS, PFNA, PFDeA, and Me-PFOSA-AcOH were found in children <15 years, while PFOS was highest in adults >60 years. Investigation into the sources and exposure pathways in Australia, in particular for children, is necessary as well as continued biomonitoring to determine the potential effects on human concentrations as a result of changes in the PFC manufacturing practices, including the cessation of production of several PFCs. 
Health & Safety Science Abstracts; Environment Abstracts; Pollution Abstracts; Consumer products; sulfonates; Bioindicators; Infants; Children; Australia, Queensland; Chemicals; ENA 02:Toxicology & Environmental Safety; H 6000:Natural Disasters/Civil Defense/Emergency Management; P 6000:TOXICOLOGY AND HEALTH 
PFAS
• 5:3 acid
     Literature Search
          WOS
     Screening Results
          Excluded/Not on Topic
• NMeFOSAA
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          Pubmed
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• ^Per- and Polyfluoroalkyl Substances (PFAS)
     PFDA (335-76-2)
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               Pubmed
               WOS
     PFNA (375-95-1)
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               Pubmed
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     PFHxS (355-46-4)
          Literature search
               Pubmed
               WOS
     PFOSA (754-91-6)
          Literature Search
               Pubmed
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     NMeFOSAA (2355-31-9)
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     5:3 acid (914637-49-3)
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• PFHxS
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               Excluded
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• PFNA
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               Exposure assessment or qualitative exposure only
• PFOSA
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          Pubmed
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          Susceptible populations