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Citation
Tags
HERO ID
3797537
Reference Type
Technical Report
Subtype
TSCA Submission
Title
Support: letter from 3M to USEPA regarding mechanistic two-year study of hepatic tumor induction in rats fed ammonium perfluoroalkyl carboxylates dated 10/11/93
Author(s)
3M Company :: 3M
Year
1993
Is Peer Reviewed?
No
Publisher
3M Company
Location
St. Paul, MN
Report Number
OTS0204926-4. 89-941000007. TSCATS/441786
Number of Pages
10
Language
English
Abstract
The test substance included ammonium perfluoroalkyl carboxylates (CAS No. 68259-11-0) which contains 93 to 97% ammonium perfluorooctanoate (CAS No. 3825-26-1), and smaller amounts of ammonium perfluoroheptanoate (CAS No. 6130-43-4) and ammonium perfluorohexanoate (CAS No. 21615-47-4). The test substance was investigated in a mechanistic bioassay investigating extra hepatic tumor induction by compounds which induce peroxisome proliferation. In this mechanistic bioassay, 300 ppm of the test substance was fed to rats as part of their diet for 2-years. In addition to an ad libitum control, a second control group was pair-fed to the 300 ppm test group to control for the effects of reduced body weight. Increased incidences of combined (single, multiple) hepatic adenomas, Leydig cell adenomas, and pancreatic acinar cell adenomas were seen in the 300 ppm test group when compared to either the ad libitum or pair-fed controls. The tumor incidences (liver, testis, pancreas) were outside the historical control incidence range for DuPont Haskell Laboratory. In addition, age- adjustment statistics also support the conclusion that the tumor incidence was elevated for the liver (both controls), pancreas (pair-fed control), and testis (pair-fed control).
Keywords
MIXTURE OF AMMONIuM PERFLUOROOCTANOATE, AM:MONIUM PERFLUOR*
TSCATS Number
TSCATS/441786
Tags
PFAS
•
^Per- and Polyfluoroalkyl Substances (PFAS)
PFHpA (375-85-9)
Literature Search
Toxline
PFHxA (307-24-4)
Literature Search
Toxline
Human Health Toxicity
•
PFAS 150
Literature Search August 2019
ToxNet
Ammonium perfluorooctanoate
•
PFBA
Protocol References
•
PFHpA
Literature Search
Toxline
Screening Results
Excluded/Not on Topic
•
PFHxA
Literature Search
Toxline
LitSearch Update: February 2018
Term Set 2: Initial Search
Literature Search
Toxline
Screening Results
Excluded/Not on Topic
Title and Abstract Screening
Tagged as Supplemental
HAWC
•
Yale PFAS Liver study
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