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HERO ID
3859042
Reference Type
Journal Article
Title
Safety evaluation of dermal exposure to phthalates: Metabolism-dependent percutaneous absorption
Author(s)
Sugino, M; Hatanaka, T; Todo, H; Mashimo, Y; Suzuki, T; Kobayashi, M; Hosoya, O; Jinno, H; Juni, K; Sugibayashi, K
Year
2017
Is Peer Reviewed?
1
Journal
Toxicology and Applied Pharmacology
ISSN:
0041-008X
EISSN:
1096-0333
Publisher
Elsevier
Location
SAN DIEGO
Volume
328
Issue
Elsevier
Page Numbers
10-17
Language
English
PMID
28506834
DOI
10.1016/j.taap.2017.05.009
Web of Science Id
WOS:000403524200002
URL
https://search.proquest.com/docview/1899405216?accountid=171501
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Abstract
Phthalates, known as reproductive toxicants and endocrine disruptors, are widely used as plasticizers in polyvinyl chloride products. The present study was conducted for risk identification of dermal exposure to phthalates. When dibutyl phthalate was applied to the skin of hairless rats and humans, only monobutyl phthalate appeared through the skin, and the permeability of the skin was higher than that after the application of the monoester directly. The inhibition of skin esterases made the skin impermeable to the metabolite following dermal exposure to dibutyl ester, whereas removal of the stratum corneum from the skin did not change the skin permeation behavior. Similar phenomena were observed for benzyl butyl phthalate. The skin permeability of monobenzyl phthalate was higher than that of monobutyl phthalate in humans, although the reverse was observed in rats. Species difference in skin permeation profile corresponded to the esterase activity of the skin homogenate. Di(2-ethylhexyl) phthalate, which was not metabolized by esterases in the skin, was not transported across the skin. These results suggest that highly lipophilic phthalates may be transported easily across the stratum corneum lipids. The water-rich viable layer may become permeable to these phthalates by their metabolism into monoesters, which are relatively hydrophilic. Skin metabolism is essential to the percutaneous absorption of phthalates. Because esterase activity has large inter-individual differences, further study will be needed for individual risk identification of dermal exposure to phthalates.
Keywords
Environmental Pollutants; Phthalic Acids; Plasticizers; Dibutyl Phthalate; 2286E5R2KE; Diethylhexyl Phthalate; C42K0PH13C; Esterases
Tags
IRIS
•
BBP (Butyl benzyl phthalate)
Literature Search
Literature Search: July 2016 - January 2017
Literature Search: February 2017 - July 2017
Pubmed
WOS
•
Dibutyl Phthalate (DBP)
Database Searches
LitSearch Jan 2017 - July 2017
WOS
LitSearch July 2017 - Sept 2018
Prior Search Overlap
WOS
•
Phthalates – Targeted Search for Epidemiological Studies
Source – all searches
Pubmed
WOS
Excluded
Source - August 2017 Update (Private)
Pubmed
WOS
Source - August 2018 Update
Pubmed
WOS
Level 1 Screen - Title & Abstract
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