Health & Environmental Research Online (HERO)


Print Feedback Export to File
3859245 
Journal Article 
Review 
Biotransformation pathways of fluorotelomer-based polyfluoroalkyl substances: a review 
Butt, CM; Muir, DC; Mabury, SA 
2014 
Yes 
Environmental Toxicology and Chemistry
ISSN: 0730-7268
EISSN: 1552-8618 
33 
243-267 
English 
The study reviews the current state of knowledge regarding the biotransformation of fluorotelomer-based compounds, with a focus on compounds that ultimately degrade to form perfluoroalkyl carboxylates (PFCAs). Most metabolism studies have been performed with either microbial systems or rats and mice, and comparatively few studies have used fish models. Furthermore, biotransformation studies thus far have predominately used the 8:2 fluorotelomer alcohol (FTOH) as the substrate. However, there have been an increasing number of studies investigating 6:2 FTOH biotransformation as a result of industry's transition to shorter-chain fluorotelomer chemistry. Studies with the 8:2 FTOH metabolism universally show the formation of perfluorooctanoate (PFOA) and, to a smaller fraction, perfluorononanoate (PFNA) and lower-chain-length PFCAs. In general, the overall yield of PFOA is low, presumably because of the multiple branches in the biotransformation pathways, including conjugation reactions in animal systems. There have been a few studies of non-FTOH biotransformation, which include polyfluoroalkyl phosphates (PAPs), 8:2 fluorotelomer acrylate (8:2 FTAC), and fluorotelomer carboxylates (FTCAs, FTUCAs). The PAPs compounds and 8:2 FTAC were shown to be direct precursors to FTOHs and thus follow similar degradation pathways. 
PFAS
• 6:2/8:2 diPAP
     Literature Search
          Pubmed
          WOS
     Screening Results
          Reviews/Reg docs
• 6:2 diPAP
     Literature Search
          Pubmed
          WOS
     Screening Results
          Reviews/Reg docs
• 8:2 diPAP
     Literature Search
          Pubmed
          WOS
     Screening Results
          Reviews/Reg docs
• FtOH 6:2
     Screening Results
          Reviews/Reg docs
• FtOH 8:2
     Literature Search
          Pubmed
          WOS
     Screening Results
          Reviews/Reg docs
• ^Per- and Polyfluoroalkyl Substances (PFAS)
     PFNA (375-95-1)
          Literature Search
               Pubmed
               WOS
     FtOH 8:2 (678-39-7)
          Literature Search
               Pubmed
               WOS
     FtOH 6:2 (647-42-7)
          Literature Search
               Pubmed
               WOS
     6:2 diPAP (57677-95-9)
          Literature Search
               Pubmed
               WOS
               Additional Strategies
     8:2 diPAP (678-41-1)
          Literature Search
               Pubmed
               WOS
     6:2/8:2 diPAP (943913-15-3)
          Literature Search
               Pubmed
               WOS
• PFNA
     Literature Search
          Exclusions
               Reviews
          Pubmed
          WOS
     Screening Results
          Reviews/Reg docs
     PFNA Literature Search pre-2019
          WOS
          Pubmed
• PFOA (335-67-1) and PFOS (1763-23-1)
     Literature Search Update (2013-2019)
          PubMed
          WOS