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5918597 
Journal Article 
Distribution of novel and legacy per-/polyfluoroalkyl substances in serum and its associations with two glycemic biomarkers among Chinese adult men and women with normal blood glucose levels 
Duan, Y; Sun, H; Yao, Y; Meng, Y; Li, Y 
2020 
Environment International
ISSN: 0160-4120
EISSN: 1873-6750 
134 
Elsevier 
105295 
English 
In recent years, the occurrence of novel per-/polyfluoroalkyl substances (PFASs) such as polyfluoroalkyl ether sulfonates (PFAESs) in human samples have aroused attention due to the change in PFASs production profile, however, the data are still lacking. Furthermore, epidemiological studies have examined the associations of PFAS exposure with glucose homeostasis, but with inconsistent results. Therefore, in this study, fasting serum samples from 252 participants with an age range from 19 to 87 years old were collected in Tianjin, China. A total of 21 target PFASs were determined to analyze the levels and distribution of novel and legacy PFASs in serum and to further evaluate the cross-sectional associations of serum PFAS concentrations with two glycemic biomarkers (i.e., fasting glucose and glycated hemoglobin (HbA1c)). 6:2 chlorinated PFAES (6:2 Cl-PFAES) and trifluoroacetic acid (TFA) were widely detected novel PFASs (greater than90%) with relatively high median concentrations (8.64 ng/mL and 8.46 ng/mL, respectively), which were second only to the two dominant legacy PFASs, i.e., perfluorooctanoic acid (PFOA, 14.83 ng/mL) and perfluorooctane sulfonic acid (14.24 ng/mL). The percentage contributions to the total known PFASs were separately 17.6% and 17.2% for 6:2 Cl-PFAES and TFA. The levels of 6:2 Cl-PFAES were significantly correlated with age and BMI, and the concentrations of TFA were also significantly correlated with age. Furthermore, 1% increase in serum PFOA and perfluorononanoic acid (PFNA) was separately significantly associated with 0.018% [95% confidence interval (CI): 0.004%, 0.033%] and 0.022% (95% CI: 0.007%, 0.037%) increment in fasting glucose levels. Similarly, 1% increase in serum perfluorohexanoic acid, PFNA, and perfluorohexane sulfonic acid was significantly associated with 0.030% (95% CI: 0.010%, 0.051%), 0.018% (95% CI: 0.003%, 0.033%), 0.007% (95% CI: 0.003%, 0.011%) increment in HbA1c levels, respectively. These findings suggested that 6:2 Cl-PFAES and TFA showed greater contributions to PFASs in serum and supported an association of exposure to PFASs with fasting glucose and HbA1c. 
PFASs; 6:2 Cl-PFAES; Fasting glucose; HbA1c; Glycemic biomarker 
PFAS
• Additional PFAS (formerly XAgency)
• Expanded PFAS SEM (formerly PFAS 430)
     Litsearch: September 2019
          PubMed
     Screened Studies
          Included
               Include (TIAB)
          Excluded
               Exclude (Full Text)
     Perfluorooctane
     Perfluoro(2-((6-chlorohexyl)oxy)ethanesulfonic acid)
• PFAS 150
     Literature Search Update December 2021
          PubMed
          WOS
     Missing 2021 searches
     Literature Search Update December 2020
          PubMed
          WOS
     Literature Search August 2019
          PubMed
          Web of Science
          Other sources
               Reference list review of included studies
     Screened Studies
          Included
               Include (TIAB)
               Include (Full Text)
     Perfluorinated compounds
     Perfluorohexanoic acid
     Perfluorooctane
     Trifluoroacetic acid
     1,1,1,3,3,3-Hexafluoro-2- (fluoromethoxy)propane
• PFAS Universe
     Data Source
          Web of Science
          Pubmed
          Screened Studies
               Included
                    Include (TIAB)
               Excluded
                    Exclude (Full Text)
     2,​2,​2-​trifluoro-Acetic acid-​d
     Perfluoro(2-((6-chlorohexyl)oxy)ethanesulfonic acid)
     Perfluorohexane
     Perfluorohexanesulfonic acid
     Perfluorohexanoic acid
     Perfluorononanoic acid
     Perfluorooctane
     Perfluorooctanesulfonic acid
     Perfluorooctanoate
     Potassium 9-chlorohexadecafluoro-3-oxanonane-1-sulfonate
     Perfluorooctanoic acid
• PFBA
     Literature Search Update 4/2022
     June 2022 Pelch Database
• PFDA
     Literature Search
          Other
               Published PFAS SEMs
     Scopus: April 2021
     June 2022 Pelch Database
     Literature Searches (through April 2023 update and post-public comment/peer review)
          Title & Abstract Screening
               Full Text Screening
                    Studies Meeting PECO
                         Human health effects studies
• PFHxA
     LitSearch Update: May 2019 - May 2020
          PubMed
          WoS
     Scopus: April 2021
     Results pulled from Pelch database May 2022
     HAWC
• PFHxS
     Database searches
          Pubmed
          WOS
          Scopus
          Pelch PFAS SEM
     Inclusion
          TiAb
          Full Text
               Human Study
• PFNA
     Literature Search
          Pubmed
          WOS
     LitSearch: May 2019 - May 2020
          PubMed
          WoS
     LitSearch: May 2020 - April 2021
          WoS
     Title and Abstract Screening
          Full Text Screening
               Studies Meeting PECO
                    Human health effects studies
     June 2022 Pelch Database
OW - HHRAB
• PFOA (335-67-1) and PFOS (1763-23-1)
     LitSearch: Feb 2019 - May 2020
          PubMed
          WoS
     Literature Search Update (Apr 2019 - Sep 2020)
          PubMed
          WOS
• PFOA and PFOS OW MCLG Approaches
     Cited in White Papers