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6315705 
Journal Article 
The short-chain perfluorinated compounds PFBS, PFHxS, PFBA and PFHxA, disrupt human mesenchymal stem cell self-renewal and adipogenic differentiation 
Liu, S; Yang, R; Yin, N; Faiola, F 
2020 
Yes 
Journal of Environmental Sciences
ISSN: 1001-0742
EISSN: 1878-7320 
SCIENCE PRESS 
BEIJING 
88 
187-199 
English 
Per- and polyfluorinated alkyl substances (PFASs) are commonly used in industrial processes and daily life products. Because they are persistent, they accumulate in the environment, wildlife and humans. Although many studies have focused on two of the most representative PFASs, PFOS and PFOA, the potential toxicity of short-chain PFASs has not yet been given sufficient attention. We used a battery of assays to evaluate the toxicity of several four-carbon and six-carbon perfluorinated sulfonates and carboxyl acids (PFBS, PFHxS, PFBA and PFHxA), with a human mesenchymal stem cell (hMSC) system. Our results demonstrate significant cyto- and potential developmental toxicity for all the compounds analyzed, with shared but also distinct mechanisms of toxicity. Moreover, the effects of PFBS and PFHxS were stronger than those of PFBA and PFHxA, but occurred at higher doses compared to PFOS or PFOA. 
Short-chain perfluorinated compounds; Human mesenchymal stem cells (hMSCs); Adipogenesis/osteogenesis; Developmental toxicity; PFBS/PFBA/PFHxS/PFHxA 
PFAS
• Additional PFAS (formerly XAgency)
     Literature Search November 2019
          Other Sources
               Reference list review of included studies
     Screened Studies
          Excluded
               Exclude (TIAB)
• PFAS 150
     Literature Search Update December 2021
          PubMed
          WOS
     Missing 2021 searches
     Literature Search Update December 2020
          PubMed
          WOS
     Literature Search August 2019
          PubMed
          Web of Science
     Perfluorinated compounds
     Perfluorobutanesulfonyl fluoride
     Perfluorohexanesulfonic acid
• PFAS Universe
     Data Source
          Web of Science
          Pubmed
     Perfluorobutanesulfonate
     Perfluorobutanesulfonic acid
     Perfluorobutanoate
     Perfluorobutanoic acid
     Perfluorohexanesulfonate
     Perfluorohexanesulfonic acid
     Perfluorohexanoate
     Perfluorohexanoic acid
     Perfluorooctanesulfonate
     Perfluorooctanesulfonic acid
     Perfluorooctanoate
     Sodium perfluorohexanesulfonate
     Perfluorooctanoic acid
• PFBA
     LitSearch: May 2019 - May 2020
          PubMed
          WoS
     Scopus: April 2021
     June 2022 Pelch Database
• PFBS
     Search
          PubMed
          WOS
     Lit Search Update: May 2019 - May 2020
          WoS
          PubMed
     Scopus: April 2021
• PFHxA
     LitSearch Update: May 2019 - May 2020
          PubMed
          WoS
     Scopus: April 2021
     Results pulled from Pelch database May 2022
     HAWC
• PFHxS
     Database searches
          Pubmed
          WOS
          Scopus
          Pelch PFAS SEM
     Supplemental
          TiAb
          In vitro or in silico studies (non-genotoxicity)
          In vivo mechanistic or MOA studies, including non-PECO routes of exposure and populations
     Literature Search Update April 2023
          Supplemental
               In vivo mechanistic or MOA studies, including non-PECO routes of exposure (e.g., nonmammalian)
               In vitro in silico (non-genotoxicity)
• PFNA
OW - HHRAB
• PFOA (335-67-1) and PFOS (1763-23-1)
     LitSearch: Feb 2019 - May 2020
          PubMed
          WoS
     Literature Search Update (Apr 2019 - Sep 2020)
          PubMed
          WOS