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6315705 
Journal Article 
The short-chain perfluorinated compounds PFBS, PFHxS, PFBA and PFHxA, disrupt human mesenchymal stem cell self-renewal and adipogenic differentiation 
Liu, S; Yang, R; Yin, N; Faiola, F 
2020 
Yes 
Journal of Environmental Sciences
ISSN: 1001-0742
EISSN: 1878-7320 
88 
187-199 
English 
Per- and polyfluorinated alkyl substances (PFASs) are commonly used in industrial processes and daily life products. Because they are persistent, they accumulate in the environment, wildlife and humans. Although many studies have focused on two of the most representative PFASs, PFOS and PFOA, the potential toxicity of short-chain PFASs has not yet been given sufficient attention. We used a battery of assays to evaluate the toxicity of several four-carbon and six-carbon perfluorinated sulfonates and carboxyl acids (PFBS, PFHxS, PFBA and PFHxA), with a human mesenchymal stem cell (hMSC) system. Our results demonstrate significant cyto- and potential developmental toxicity for all the compounds analyzed, with shared but also distinct mechanisms of toxicity. Moreover, the effects of PFBS and PFHxS were stronger than those of PFBA and PFHxA, but occurred at higher doses compared to PFOS or PFOA. 
Short-chain perfluorinated compounds; Human mesenchymal stem cells (hMSCs); Adipogenesis/osteogenesis; Developmental toxicity; PFBS/PFBA/PFHxS/PFHxA 
• PFBA
     LitSearch: May 2019 - May 2020
          PubMed
          WoS
• PFBS
     LitSearch: May 2019 - May 2020
          WoS
          PubMed
• PFHxA
     LitSearch: May 2019 - May 2020
          PubMed
          WoS
• PFHxS
     LitSearch: May 2019 - May 2020
          PubMed
          WoS
• PFOA (335-67-1) and PFOS (1763-23-1)
     LitSearch: Feb 2019 - May 2020
          WoS
          PubMed
     Literature Search Update (Apr 2019 - Sep 2020)
          PubMed
          WOS