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HERO ID
1597640
Reference Type
Journal Article
Title
Urinary phthalate metabolites are associated with body mass index and waist circumference in Chinese school children
Author(s)
Wang, H; Zhou, Y; Tang, C; He, Y; Wu, J; Chen, Y; Jiang, Q
Year
2013
Is Peer Reviewed?
1
Journal
PLoS ONE
EISSN:
1932-6203
Volume
8
Issue
2
Page Numbers
e56800
Language
English
PMID
23437242
DOI
10.1371/journal.pone.0056800
Web of Science Id
WOS:000315184200166
URL
https://search.proquest.com/docview/1330882599?accountid=171501
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Abstract
BACKGROUND:
Lab studies have suggested that ubiquitous phthalate exposures are related to obesity, but relevant epidemiological studies are scarce, especially for children.
OBJECTIVE:
To investigate the association of phthalate exposures with body mass index (BMI) and waist circumference (WC) in Chinese school children.
METHODS:
A cross-sectional study was conducted in three primary and three middle schools randomly selected from Changning District of Shanghai City of China in 2011-2012. According to the physical examination data in October, 2011, 124 normal weight, 53 overweight, and 82 obese students 8-15 years of age were randomly chosen from these schools on the basis of BMI-based age- and sex-specific criterion. First morning urine was collected in January, 2012, and fourteen urine phthalate metabolites (free plus conjugated) were determined by ultra-performance liquid chromatography coupled to tandem mass spectrometry. Multiple linear regression was used to explore the associations between naturally log-transformed urine phthalate metabolites and BMI or WC.
RESULTS:
The urine specific gravity-corrected concentrations of nine urine phthalate metabolites and five molar sums were positively associated with BMI or WC in Chinese school children after adjustment for age and sex. However, when other urine phthalate metabolites were included in the models together with age and sex as covariables, most of these significant associations disappeared except for mono (2-ethylhexyl) phthalate (MEHP) and monoethyl phthalate (MEP). Additionally, some associations showed sex- or age-specific differences.
CONCLUSIONS:
Some phthalate exposures were associated with BMI or WC in Chinese school children. Given the cross-sectional nature of this study and lack of some important obesity-related covariables, further studies are needed to confirm the associations.
Keywords
Sciences: Comprehensive Works; Phthalates; Metabolites; Body mass index; Schools; Obesity; Specific gravity; Childhood obesity; Mass spectrometry; Hormones; Liquid chromatography; Bisphenol A; Children; Exposure; Body weight; Cross sections; Studies; Epidemiology; Body mass; Body size; Mass spectroscopy
Tags
IRIS
•
BBP (Butyl benzyl phthalate)
•
Dibutyl Phthalate (DBP)
•
Diethyl phthalate (DEP)
Database searches
Jan 2020 update
PubMed
Web of Science
Additional Strategies
Primary source of health effects
Human health effects studies
•
Diisobutyl Phthalate (DIBP) Final
Additional Search Strategies
References obtained during assessment process
Primary Source of Health Effects Studies
Human health effects studies
Cited in September 2014 DIBP Preliminary Materials
•
Phthalates – Targeted Search for Epidemiological Studies
Source – all searches
Pubmed
WOS
Included
DEHP
DBP
DiBP
DEP
Source – no date limit through June 2013 (Private)
Pubmed
WOS
Source - Dec 2013 Update (Private)
WOS
Source - Jun 2014 Update (Private)
WOS
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