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HERO ID
3972697
Reference Type
Journal Article
Title
Estrogenicity assessment of membrane concentrates from landfill leachate treated by the UV-Fenton process using a human breast carcinoma cell line
Author(s)
Hou, C; Lu, G; Zhao, L; Yin, P; Zhu, L
Year
2017
Is Peer Reviewed?
Yes
Journal
Chemosphere
ISSN:
0045-6535
EISSN:
1879-1298
Publisher
Elsevier
Location
OXFORD
Volume
180
Issue
Elsevier
Page Numbers
192-200
Language
English
PMID
28407549
DOI
10.1016/j.chemosphere.2017.04.033
Web of Science Id
WOS:000401880500023
URL
https://search.proquest.com/docview/1888684171?accountid=171501
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Abstract
Membrane concentrates (MCs) are generated when membranes are used to concentrate landfill leachate. It contains high concentrations of inorganic and organic environmental pollutants, which are highly toxic and carcinogenic. In this paper, the proliferation effect (PE) from MC before and after treatment with the UV-Fenton process was assessed using the human breast carcinoma cell line MCF-7. The highest value of 116% was found at 5% (v/v) concentration after a 10 min reaction. Phthalic acid esters (PAEs) play an important role in the MC estrogenicity. Estrogen simulation solutions (ESS) of PAEs were prepared to simulate the changes in estrogenic active substances during the UV-Fenton process. The ESS degradation conformed to the first-order kinetics model. The estrogenicity decreased after an initial increase until it acted in a non-estrogenic manner. Convincingly, the intermediates were determined by GC/MS, and the estrogenicity was assessed during the degradation process. The estrogenicity was highly related to the generation of intermediates and the PAE concentration. The results provide guidance for UV-Fenton application in MC estrogenicity reduction.
Keywords
Estrogens; Water Pollutants, Chemical; Estrone; 2DI9HA706A; Hydrogen Peroxide; BBX060AN9V; E1UOL152H7; Index Medicus; Intermediate analysis; Estrogenicity assessment; Membrane concentrates of landfill leachate; Advanced oxidation process; Endocrine disrupting chemicals; Oxidation-Reduction; Cell Line, Tumor; Breast Neoplasms; Waste Disposal, Fluid -- methods; Estrogens -- toxicity; Water Pollutants, Chemical -- toxicity
Tags
IRIS
•
Dibutyl Phthalate (DBP)
Database Searches
LitSearch Jan 2017 - July 2017
Pubmed
•
Phthalates – Targeted Search for Epidemiological Studies
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Pubmed
WOS
Toxnet
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Source - August 2017 Update (Private)
Pubmed
Toxnet
WOS
Source - August 2018 Update
Pubmed
WOS
Toxline
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