US EPA

675053 

Journal Article 

Determination of phthalate esters in cosmetics by gas chromatography with flame ionization detection and mass spectrometric detection 

Chen, H; Wang, C; Wang, X; Hao, N; Liu, J 

2005 

Yes 

International Journal of Cosmetic Science
ISSN: 0142-5463
EISSN: 1468-2494 

27 

4 

205-210 

English 

18492189 

10.1111/j.1467-2494.2005.00249. 

https://www.scopus.com/inward/record.uri?eid=2-s2.0-22844431754&doi=10.1111%2fj.1467-2494.2005.00249.x&partnerID=40&md5=14f75dca86d37e8a911cafb22126395c
Exit
 

A gas chromatography coupled with flame ionization detection (GC-FID) and mass spectrometric detection (MSD) method was developed to determine the six kinds of phthalate esters [dimethyl phthalate (DMP), diethyl phthalate (DEP), di-n-butyl phthalate (DBP), benzyl butyl phthalate (BBP), di(2-ethylhexyl) phthalate (DEHP) and di-n-octyl phthalate (DOP)] in cosmetics (solid, cream and liquid cosmetics). The cosmetics were extracted with methanol by ultrasonic and then separated with high-speed centrifugation. The upper clear layer was dried and filtered through a 0.45 mum pore diameter filter. The filtrate was injected into GC-FID/GC-MS for detection. GC-FID chromatogram was applied for qualitative analysis, external standard method was used for quantitative analysis. Confirmation of phthalate presence was undertaken by GC-EI-MS. The recovery range of all phthalates were between 92.0 and 110.0% with relative standard deviations between 1.95 and 5.92%. The low detection limits of the method were: 0.1 ng for DMP, DEP, DBP and BBP, 0.5 ng for DEHP and DOP. The method had advantages of high precision and sensitivity, simplicity of pretreatment. The method can be used to test the six kinds of phthalate esters in cosmetics. 

Cosmetics; GC-FID; GC-MS; Phthalate esters