US EPA

2347469 

Journal Article 

Determination of phthalates and their by-products in tissues of roach (Rutilus rutilus) from the Orge river (France) 

Valton, AS; Serre-Dargnat, C; Blanchard, M; Alliot, F; Chevreuil, M; Teil, MJ 

2014 

Yes 

Environmental Science and Pollution Research
ISSN: 0944-1344
EISSN: 1614-7499 

SPRINGER HEIDELBERG 

HEIDELBERG 

21 

22 

12723-12730 

English 

24965007 

10.1007/s11356-014-3213-0 

WOS:000344546900012 

https://search.proquest.com/docview/1788597227?accountid=171501
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Seven phthalate by-products were investigated for the first time, in target tissues of roach from a contaminated river of the Ile-de-France district. All parent phthalates were bioaccumulated in liver and muscle and liver contents were correlated with river concentrations (p < 0.01). All metabolites were found in liver, plasma and bile. The mono-iso-butyl phthalate (MiBP; 1.6 μg g(-1) dw of liver), followed by mono-n-butyl phthalate (MnBP; 1.5 μg g(-1) dw of liver) were the most abundant ones. Among the three metabolites of di-ethylhexyl phthalate (DEHP), mono (2-ethylhexyl) phthalate (MEHP) predominated in bile (15.5 ng ml(-1)) and liver (0.237 μg g(-1) dw), whereas in plasma, it was mono (2-ethyl-5-hydroxyhexyl) phthalate - MEHHP (214 ng ml(-1)). In liver, MEHP/DEHP ratios ranged from 0.04 to 0.2. Among the oxidized metabolites, only mono (2-ethyl-5-oxohexyl) phthalate (MEOHP) was correlated (p < 0.05) with parent DEHP and appeared to be a more reliable marker of DEHP impact than the monoester. 

Phthalate; By-product; Roach; Liver; Plasma; Bile