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1424952 
Journal Article 
Polyfluoroalkyl chemicals in house dust 
Kato, K; Calafat, AM; Needham, LL 
2009 
Yes 
Environmental Research
ISSN: 0013-9351
EISSN: 1096-0953 
109 
518-523 
English 
We developed a high throughput analytical method using on-line solid phase extraction coupled with isotope dilution high-performance liquid chromatography-tandem mass spectrometry (on-line SPE-HPLC-MS/MS) to simultaneously determine the concentrations of 17 polyfluoroalkyl chemicals (PFCs) in house dust. The sample preparation includes dispersion of the dust samples in 0.1 M formic acid:MeOH (1:1), followed by agitation and filtration, addition of the isotope-labeled internal standard solution to the filtrate, and analysis by on-line SPE-HPLC-MS/MS. The limits of quantitation were <4.0 ng/g. The method accuracies ranged between 73.2% and 100.2% for the different analytes at two spike levels. We confirmed the validity of the method by analyzing 39 household dust samples collected in 2004. Of the 17 PFCs measured, 6 of them--perfluorobutane sulfonate (PFBuS), N-ethyl-perfluorooctane sulfonamide, 2-(N-ethyl-perfluorooctane sulfonamido) acetic acid (Et-PFOSA-AcOH), 2-(N-methyl-perfluorooctane sulfonamido) ethanol (Me-PFOSA-EtOH), perfluorohexane sulfonate (PFHxS), and perfluorooctane sulfonate (PFOS)--had detection frequencies >70%. We detected PFOS, PFBuS, and PFHxS at the highest median concentration, followed by Et-PFOSA-AcOH and Me-PFOSA-EtOH. 
Dust; Polyfluoroalkyl chemicals; Exposure; PFCs 
• NEtFOSAA
     Literature Search
          Pubmed
          WOS
     Screening Results
          Excluded/Not on Topic
• ^Per- and Polyfluoroalkyl Substances (PFAS)
     PFBS (375-73-5)
          Literature Search
               Pubmed
               WOS
     PFHxS (355-46-4)
          Literature search
               Pubmed
               WOS
     PFOSA (754-91-6)
          Literature Search
               Pubmed
               WOS
     NEtFOSAA (2991-50-6)
          Literature Search
               Pubmed
               WOS
• PFBS
          Pubmed
          WOS
          Excluded/Not on Topic
     Search
          PubMed
          WOS
     Included
          Supporting References
     Excluded
          WOS
• PFHxS
     Literature Search
          PubMed
          WOS
     Screening Results
          Excluded/Not on Topic
• PFOSA
     Literature Search
          Pubmed
          WOS
     Screening Results
          Excluded/Not on Topic