US EPA

1597663 

Journal Article 

The association between some endocrine disruptors in human plasma and the occurrence of congenital hypothyroidism 

Jung, H; Hong, Y; Lee, D; Pang, K; Kim, Y 

2013 

Yes 

Environmental Toxicology and Pharmacology
ISSN: 1382-6689
EISSN: 1872-7077 

35 

2 

278-283 

English 

23376177 

10.1016/j.etap.2013.01.002 

WOS:000316591100018 

https://search.proquest.com/docview/1733511250?accountid=171501
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Congenital hypothyroidism is a common pediatric endocrine disease. Endocrine disruptors are indicated as a possible cause of congenital hypothyroidism. We investigated the associations between endocrine disruptors and the occurrence of congenital hypothyroidism and passage of target compounds from the mother. The levels of phthalates (DEHP, MEHP, DBP, MBP and PA), alkylphenols (n-NP and t-OP), bisphenol, and isoflavones (equol, daidzein and genistein) were determined by gas chromatography-mass spectrometry (GC-MS) in infants. t-OP and PA concentrations in the patient group were significantly higher than in normal infants. Genistein concentrations in normal infants were significantly higher than in patients. We compared the plasma levels of target compounds in infants with their mothers. There was no correlation with the passage of endocrine disruptors and isoflavones from the mothers, except for t-OP, which was weakly correlated between mother and infant. 

Congenital hypothyroidism; Endocrine disruptors; Isoflavones; Association; GC-MS