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Citation
Tags
HERO ID
3856851
Reference Type
Book/Book Chapter
Title
Toxicology data for alternative "short-chain" fluorinated substances
Author(s)
Buck, RC
Year
2015
Publisher
Springer International Publishing
Location
New York, NY
Book Title
Toxicological Effects of Perfluoroalkyl and Polyfluoroalkyl Substances
Page Numbers
451-477
Language
English
DOI
10.1007/978-3-319-15518-0_17
Web of Science Id
WOS:000364811700018
Relationship(s)
is a chapter of
3980931
Toxicological effects of perfluoroalkyl and polyfluoroalkyl substances
Abstract
Per- and poly-fluoroalkyl substances (PFASs) have been manufactured and widely used since the 1950s in numerous industrial and consumer applications. However, various perfluoroalkyl acids (PFAAs) such as perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA), which have been manufactured and sold themselves and are impurities and breakdown products from numerous commercial per- and poly-fluoroalkyl surfactant and polymeric products, have been found widely in the environment. Concerns about the potential environmental impact of "long-chain" PFAAs has led to a substantial phase out of production of PFOS and PFOA and related compounds. Manufacturers have moved to production of alternative products which cannot be transformed in to long-chain PFAAs. This chapter provides an overview of available toxicology data for alternative fluorinated technologies including: short-chain fluorotelomer, short-chain electrochemical fluorination, perfluoropolyether, fluorinated oxetane, per- and poly-fluoroalkyl ether carboxylates and short-chain perfluoroalkyl acids.
Keywords
Perfluoroalkyl; Polyfluoroalkyl; Acids; Toxicology; Alternative; Short-chain; Fluorotelomer; Electrochemical fluorination; Perfluoropolyether; Oxetane
Editor(s)
DeWitt, JC
Series
Molecular and Integrative Toxicology
ISBN
9783319155173
Tags
PFAS
•
Expanded PFAS SEM (formerly PFAS 430)
Perfluorooctane
•
FtOH 6:2
Screening Results
Reviews/Reg docs
•
^Per- and Polyfluoroalkyl Substances (PFAS)
PFOA (335-67-1) and PFOS (1763-23-1)
Literature Search – Adverse outcome pathway (2015-present)
WOS
PFBS (375-73-5)
Literature Search
WOS
PFHxA (307-24-4)
Literature Search
WOS
FtOH 6:2 (647-42-7)
Literature Search
WOS
•
PFBS
WOS
Reviews/Reg docs
Search
WOS
Excluded
•
PFHxA
Literature Search
WOS
Literature Search
WOS
Screening Results
Reviews/Reg docs
Title and Abstract Screening
Full Text Screening
Excluded
Review, commentary, or letter
HAWC
•
PFNA
•
PFOA (335-67-1) and PFOS (1763-23-1)
Literature Search – Adverse outcome pathway (2015-present)
WOS
Screening Results
Reviews/Reg docs
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