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4238434 
Journal Article 
Half-lives of PFOS, PFHxS and PFOA after end of exposure to contaminated drinking water 
Li, Y; Fletcher, T; Mucs, D; Scott, K; Lindh, CH; Tallving, P; Jakobsson, K 
2018 
Occupational and Environmental Medicine
ISSN: 1351-0711
EISSN: 1470-7926 
BMJ PUBLISHING GROUP 
LONDON 
75 
46-51 
English 
is supplemented by 11350759 Supplement:
BACKGROUND: Municipal drinking water contaminated with perfluorinated alkyl acids had been distributed to one-third of households in Ronneby, Sweden. The source was firefighting foam used in a nearby airfield since the mid-1980s. Clean water was provided from 16 December 2013.

OBJECTIVE: To determine the rates of decline in serum perfluorohexane sulfonate (PFHxS), perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA), and their corresponding half-lives.

METHODS: Up to seven blood samples were collected between June 2014 and September 2016 from 106 participants (age 4-84 years, 53% female).

RESULTS: Median initial serum concentrations were PFHxS, 277 ng/mL (range 12-1660); PFOS, 345 ng/mL (range 24-1500); and PFOA, 18 ng/mL (range 2.4-92). The covariate-adjusted average rates of decrease in serum were PFHxS, 13% per year (95% CI 12% to 15%); PFOS, 20% per year (95% CI 19% to 22%); and PFOA, 26% per year (95% CI 24% to 28%). The observed data are consistent with a first-order elimination model. The mean estimated half-life was 5.3 years (95% CI 4.6 to 6.0) for PFHxS, 3.4 years (95% CI 3.1 to 3.7) for PFOS and 2.7 years (95% CI 2.5 to 2.9) for PFOA. The interindividual variation of half-life was around threefold when comparing the 5th and 95th percentiles. There was a marked sex difference with more rapid elimination in women for PFHxS and PFOS, but only marginally for PFOA.

CONCLUSIONS: The estimated half-life for PFHxS was considerably longer than for PFOS and PFOA. For PFHxS and PFOS, the average half-life is shorter than the previously published estimates. For PFOA the half-life is in line with the range of published estimates. 
Occupational Health And Safety; half-life; Half life; Population; Groundwater; Households; Water pollution; Drinking water; Blood & organ donations; Fire fighting; Toxicology; Perfluoro compounds; Perfluorohexane 
PFAS
• Additional PFAS (formerly XAgency)
• Expanded PFAS SEM (formerly PFAS 430)
     Litsearch: September 2019
          PubMed
          Web of Science
     Not prioritized for screening
     Perfluorooctane
     Potassium perfluorooctanoate
     Sodium perfluorooctanoate
• PFAS 150
     Literature Search Update December 2020
          PubMed
          WOS
     Literature Search August 2019
          PubMed
          Web of Science
     Not prioritized for screening
     Ammonium perfluorooctanoate
     Perfluorohexanesulfonic acid
     Perfluorooctane
     Perfluorooctanesulfonic acid
     Perfluorooctanoic acid
• PFAS Universe
     Data Source
          Web of Science
          Pubmed
     Perfluorohexane
     Perfluorohexanesulfonate
     Perfluorohexanesulfonic acid
     Perfluorooctane
     Perfluorooctanesulfonate
     Perfluorooctanesulfonic acid
     Perfluorooctanoate
     Sodium perfluorohexanesulfonate
     Perfluorooctanoic acid
• PFBA
     Supplemental References
• PFBS
• PFHxS
     Database searches
          Pubmed
          Toxline
          WOS
          Scopus
          Other
     Inclusion
          TiAb
          Full Text
               Human Study
     Supplemental
          Full Text
• PFNA
     Litsearch Update 2017-2018
          Pubmed
          Toxline
     Literature Search
          Pubmed
          Toxline
     PFNA May 2019 Update
          Toxnet
     Title and Abstract Screening
          Full Text Screening
               Excluded
                    Not PFNA
          Tagged as Supplemental
               ADME
               Exposure assessment or qualitative exposure only
               Other PFAS
• PFOA (335-67-1) and PFOS (1763-23-1)
     Screening Results
          Toxicokinetic studies
               ADME
     Literature Search Update (2013-2019)
          PubMed
          WOS
• PFOA and PFOS OW MCLG Approaches
     Cited in White Papers