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1290849 
Journal Article 
Perfluorooctanesulfonate and related fluorochemicals in human blood from several countries 
Kannan, K; Corsolini, S; Falandysz, J; Fillmann, G; Kumar, KS; Loganathan, BG; Mohd, MA; Olivero, J; Van Wouwe, N; Yang, JH; Aldoust, KM 
2004 
Yes 
Environmental Science and Technology
ISSN: 0013-936X
EISSN: 1520-5851 
38 
17 
4489-4495 
English 
Perfluorooctanesulfonyl fluoride based compounds have been used in a wide variety of consumer products, such as carpets, upholstery, and textiles. These compounds degrade to perfluorooctanesulfonate (PFOS), a persistent metabolite that accumulates in tissues of humans and wildlife. Previous studies have reported the occurrence of PFOS, perfluorohexanesulfonate (PFHxS), perfluorooctanoate (PFOA), and perfluorooctanesulfonamide (PFOSA) in human sera collected from the United States. In this study, concentrations of PFOS, PFHxS, PFOA, and PFOSA were measured in 473 human blood/serum/plasma samples collected from the United States, Colombia, Brazil, Belgium, Italy, Poland, India, Malaysia, and Korea. Among the four perfluorochemicals measured, PFOS was the predominant compound found in blood. Concentrations of PFOS were the highest in the samples collected from the United States and Poland (>30 ng/mL); moderate in Korea, Belgium, Malaysia, Brazil, Italy, and Colombia (3 to 29 ng/mL); and lowest in India (<3 ng/mL). PFOA was the next most abundant perfluorochemical in blood samples, although the frequency of occurrence of this compound was relatively low. No age- or gender-related differences in the concentrations of PFOS and PFOA were found in serum samples. The degree of association between the concentrations of four perfluorochemicals varied, depending on the origin of the samples. These results suggested the existence of sources with varying levels and compositions of perfluorochemicals, and differences in exposure patterns to these chemicals, in various countries. In addition to the four target fluorochemicals measured, qualitative analysis of selected blood samples showed the presence of other perfluorochemicals such as perfluorodecanesulfonate (PFDS), perfluoroheptanoic acid (PFHpA), perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), perfluorododecanoic acid (PFDoA), and perfluoroundecanoic acid (PFUnDA) in serum samples, at concentrations approximately 5- to 10-fold lower than the concentration of PFOS. Further studies should focus on identifying sources and pathways of human exposure to perfluorochemicals. 
Alkanesulfonic Acids; Caprylates; Environmental Pollutants; Fluorocarbons; Sulfonamides; Sulfonic Acids; perfluorohexanesulfonic acid; 355-46-4; perfluorooctanesulfonamide; 80AM718FML; perfluorooctanoic acid; 947VD76D3L; perfluorooctane sulfonic acid; 9H2MAI21CL; Index Medicus; Floors and Floorcoverings; Demography; United States; Malaysia; Environmental Exposure; Textiles; Belgium; Alkanesulfonic Acids -- blood; Environmental Monitoring; Caprylates -- blood; Sulfonamides -- blood; Environmental Pollutants -- blood; Fluorocarbons -- blood; Sulfonic Acids -- blood 
PFAS
• ^Per- and Polyfluoroalkyl Substances (PFAS)
     PFDoA (307-55-1)
          Literature Search
               Pubmed
               WOS
     PFUnA (2058-94-8)
          Literature Search
               Pubmed
               WOS
     PFDA (335-76-2)
          Literature Search
               Pubmed
               WOS
     PFNA (375-95-1)
          Literature Search
               Pubmed
               WOS
     PFHpA (375-85-9)
          Literature Search
               Pubmed
               WOS
     PFDS (335-77-3)
          Literature Search
               Pubmed
               WOS
     PFHxS (355-46-4)
          Literature search
               Pubmed
               WOS
     PFOSA (754-91-6)
          Literature Search
               Pubmed
               WOS
• PFBA
     Protocol References
• PFDA
     Literature Search
          Pubmed
          WOS
     Screening Results
          Excluded/Not on Topic
     Title and Abstract Screening
          Tagged as Supplemental
               Exposure assessment or qualitative exposure only
• PFDoA
     Literature Search
          Pubmed
          WOS
     Screening Results
          Excluded/Not on Topic
• PFDS
     Literature Search
          Pubmed
          WOS
• PFHpA
     Literature Search
          Pubmed
          WOS
     Screening Results
          Excluded/Not on Topic
• PFHxS
     Literature Search
          PubMed
          Toxline
          WOS
     Screening Results
          Excluded/Not on Topic
               PubMed
     Title and Abstract Screening
          Excluded
               Not relevant to PECO
• PFNA
     PFNA Literature Search pre-2019
          Pubmed
          WOS
     Literature Search
          Pubmed
          WOS
     Screening Results
          Excluded/Not on Topic
     Title and Abstract Screening
          Excluded
               Not relevant to PECO
• PFOSA
     Literature Search
          Pubmed
          WOS
     Screening Results
          Susceptible populations
• PFUnA
     Literature Search
          Pubmed
          WOS
     Screening Results
          Excluded/Not on Topic