Jump to main content
US EPA
United States Environmental Protection Agency
Search
Search
Main menu
Environmental Topics
Laws & Regulations
About EPA
Health & Environmental Research Online (HERO)
Contact Us
Print
Feedback
Export to File
Search:
This record has one attached file:
Add More Files
Attach File(s):
Display Name for File*:
Save
Citation
Tags
HERO ID
3230103
Reference Type
Journal Article
Title
Phthalate ester concentrations in blood serum, urine and endometrial tissues of Chinese endometriosis patients
Author(s)
Sun, J; Chen, B; Zhang, LQ; Zhao, D; Li, SG
Year
2016
Is Peer Reviewed?
Yes
Journal
International Journal of Clinical and Experimental Medicine
ISSN:
1940-5901
Volume
9
Issue
2
Page Numbers
3808-3819
Language
English
Web of Science Id
WOS:000374655200393
Abstract
Objective: To explore differences of phthalic acid ester (PAE) concentrations in serum and urine as well as endometrial tissues in patients diagnosed with endometriosis (EM) compared to healthy controls in Shanghai.
Patients and methods: We designed a single-center case-control study based on the measurement of PAE concentrations in serum and urine of patients and controls as well as in pathological tissues from EM patients which were measured using either high performance liquid and/or gas chromatography. A total of 289 female subjects were included in the study (115 cases diagnosed with EM and 174 healthy women as controls).
Results: Positive detection rates of Dibutyl phthalate (DBP) and Di (2-ethylhexyl) phthalate (DEHP) were > 90% in both measured groups for all measurements, but for diethyl phthalate (DEP) the range was from 0-16.4%. The serum DBP and DEHP concentrations in patients with EM were significantly higher than in healthy women (P < 0.05). The urine concentration of primary DEHP metabolites (Sigma DEHP) was also higher in EM patients (P < 0.05). In patients diagnosed with EM, DBP and DEHP concentrations in pathological tissues were 4 and 14.4 times higher respectively, as those in serum.
Conclusion: Significantly enhanced blood serum DBP and DEHP concentrations and significant increases of their primary metabolites in urine of EM patients compared to the controls indicated that PAE affected EM. In addition, the high concentration of DBP and DEHP in resected endometrial tissues of EM patients supported this finding.
Keywords
endometriosis; phthalic acid ester; DEHP; DBP; DEHP metabolite
Tags
IRIS
•
Dibutyl Phthalate (DBP)
Database Searches
Litsearch Jan 2016 - July 2016
WOS
LitSearch Jul 2016 - Jan 2017
Prior search overlap
WoS
Studies with Health Effects Data
Human health effects studies
•
Diethyl phthalate (DEP)
Database searches
Jun 2016 update
Web of Science
Jan 2017 update
Prior search overlap
Web of Science
Jan 2020 update
Web of Science
Primary source of health effects
Human health effects studies
•
Phthalates – Targeted Search for Epidemiological Studies
Source – all searches
WOS
Included
DEHP
DBP
DiBP
DEP
Source - Jun 2016 Update (Private)
WOS
Source - Dec 2016 Update (Private)
WOS
Home
Learn about HERO
Using HERO
Search HERO
Projects in HERO
Risk Assessment
Transparency & Integrity