Health & Environmental Research Online (HERO)


Print Feedback Export to File
4220306 
Journal Article 
Biomonitoring PFAAs in blood and semen samples: Investigation of a potential link between PFAAs exposure and semen mobility in China 
Song, X; Tang, S; Zhu, H; Chen, Z; Zang, Z; Zhang, Y; Niu, X; Wang, X; Yin, H; Zeng, F; He, C 
2018 
Yes 
Environment International
ISSN: 0160-4120
EISSN: 1873-6750 
Elsevier 
113 
Elsevier 
50-54 
English 
Perfluoroalkyl acids (PFAAs) have been suspected to act as endocrine disruptors and adversely affect human reproductive health. We aimed to investigate the association between PFAAs in blood and semen, explore a potential link between PFAAs exposure and semen quality in the population of the Pearl River Delta (PRD) region in China, one of the "world factories". The monitoring results demonstrated that the population (103 male participants) from the PRD region in this study had higher PFAAs levels in blood and semen than some other areas in China. PFOS was found at the highest mean concentrations of 118.16 ng/mL in blood and 5.31 ng/mL in semen among the nine PFAAs. Significant associations were found between concentrations of several analytes in blood and semen, including Σ9 PFAAs (r = 0.475, P < .01), PFOA (r = 0.215, P = .029), PFHS (r = 0.458, P < .01) and PFOS (r = 0.981, P < .01). BMI was the most important factor to PFAAs, but there was no significant difference in PFAAs concentrations in blood and semen collected from participants with different smoking and drinking habits, education background and occupations. Negative correlations were significantly observed between sperm motility and PFBA, PFPeA, PFHxA, PFBS, PFOA, PFHS, PFOS and Σ9PFAAs in semen. Therefore, exposure to PFAAs may result in a decline in semen mobility in participants from the PRD region. 
Perfluoroalkyl acids; Reproductive toxicity; Human biomonitoring; Pearl River Delta 
• PFBA
     Literature Search
          Pubmed
     Literature Search Update 5/2019
          PubMed
          WOS
     Screening Results
          Human/Epi studies
               Repro tox
• PFBS
     Search
          PubMed
     Included
          Met PECO Criteria
               Human
          PubMed
• PFHxA
     Literature Search: February 2018 Update
          PubMed
     Literature Search
          Pubmed
     Title and Abstract Screening
          Full Text Screening
               Studies Meeting PECO
                    Human health effects studies
• PFHxS
     Literature Search
          PubMed
          Toxline
               PubMed
• PFNA
     Literature Search
          Pubmed
          Toxline
     PFNA May 2019 Update
          Toxnet
• PFOA (335-67-1) and PFOS (1763-23-1)
     Literature Search Update (2013-2019)
          PubMed
          WOS