Distribution of novel and well-known poly- and perfluoroalkyl substances (PFASs) in human serum, plasma, and whole blood
Poothong, S; Thomsen, C; Padilla-Sanchez, JA; Papadopoulou, E; Haug, LS
Currently, there is limited knowledge on the distribution of poly- and perfluoroalkyl substances (PFASs) in different blood matrices, particularly for novel PFASs such as polyfluoroalkyl phosphate esters (PAPs) and perfluoroalkyl phosphonates (PFPAs). To explore this, serum, plasma, and whole blood from 61 adults in Oslo, Norway were collected. The largest number of PFASs were detected in whole blood. For PAPs and PFPAs, the highest frequencies of detection and concentrations were observed in plasma. PAPs contributed to 8% of total PFASs in plasma (median, 0.81 ng mL-1). Perfluorohexylphosphonate (PFHxPA) was the dominant PFPA, regardless of blood matrix. The relative composition profiles of PFASs in blood matrices differed. For some specific PFASs such as perfluorooctanesulfonamide (PFOSA) and perfluorohexanoate (PFHxA), the highest concentrations were observed in whole blood. The PFAS concentration ratios varied between blood matrices, depending on the compounds. However, similar ratios were observed for 6:2 polyfluoroalkyl phosphate diester (6:2diPAP) as well as well-known PFASs such as perfluorooctanesulfonate (PFOS) and perfluorooctanoate (PFOA). Besides the determination of 25 PFASs in human blood, this study also lead to better understanding of biomonitoring data from different blood matrices, which is key knowledge for performing both exposure assessments and epidemiological studies.
Alkanesulfonic Acids; Environmental Monitoring; Environmental Pollutants; Fluorocarbons; Oslo [Norway]; Matrix algebra; fluorophosphonic acid derivative; n ethyl perfluorooctanesulfonamide; n methyl perfluorooctanesulfonamide; organofluorine derivative; pefluorobutanesulfonate; pefluoroheptanoate; perfluoroalkanoic acid; perfluorodecanesulfonate; perfluorodecanoate; perfluorodecylphosphonate; perfluorododecanoate; perfluoroheptanesulfonate; perfluorohexanoic acid; perfluorohexylphosphonate; perfluorooctanesulfonamide; perfluorooctanesulfonic acid; perfluorooctanoic acid; perfluorooctylphosphonate; perfluoropentanoate; perfluorotetradecanoate; perfluorotridecanoate; perfluoroundecanoic acid; polyfluoroalkyl phosphate diester; polyfluoroalkyl phosphate ester; polyfluoroalkyl phosphate monoester; sulfonamide; unclassified drug; alkanesulfonic acid; fluorocarbon; Blood matrix; Composition profile; Concentration ratio; High frequency HF; Human serum blood; Perfluoroalkyl substances; Phosphate esters; Phosphonates; Substance concentrations; Whole blood; biochemical composition; chemical compound; concentration (composition); detection method; Article; bioaccumulation; biological monitoring; biotransformation; blood analysis; blood level; chemical composition; limit of detection; measurement accuracy; measurement precision; measurement repeatability; quality control; pollutant