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4239163 
Journal Article 
Distribution of novel and well-known poly- and perfluoroalkyl substances (PFASs) in human serum, plasma, and whole blood 
Poothong, S; Thomsen, C; Padilla-Sanchez, JA; Papadopoulou, E; Haug, LS 
2017 
Environmental Science & Technology
ISSN: 0013-936X
EISSN: 1520-5851 
AMER CHEMICAL SOC 
WASHINGTON 
51 
22 
13388-13396 
English 
Currently, there is limited knowledge on the distribution of poly- and perfluoroalkyl substances (PFASs) in different blood matrices, particularly for novel PFASs such as polyfluoroalkyl phosphate esters (PAPs) and perfluoroalkyl phosphonates (PFPAs). To explore this, serum, plasma, and whole blood from 61 adults in Oslo, Norway were collected. The largest number of PFASs were detected in whole blood. For PAPs and PFPAs, the highest frequencies of detection and concentrations were observed in plasma. PAPs contributed to 8% of total PFASs in plasma (median, 0.81 ng mL-1). Perfluorohexylphosphonate (PFHxPA) was the dominant PFPA, regardless of blood matrix. The relative composition profiles of PFASs in blood matrices differed. For some specific PFASs such as perfluorooctanesulfonamide (PFOSA) and perfluorohexanoate (PFHxA), the highest concentrations were observed in whole blood. The PFAS concentration ratios varied between blood matrices, depending on the compounds. However, similar ratios were observed for 6:2 polyfluoroalkyl phosphate diester (6:2diPAP) as well as well-known PFASs such as perfluorooctanesulfonate (PFOS) and perfluorooctanoate (PFOA). Besides the determination of 25 PFASs in human blood, this study also lead to better understanding of biomonitoring data from different blood matrices, which is key knowledge for performing both exposure assessments and epidemiological studies. 
Alkanesulfonic Acids; Environmental Monitoring; Environmental Pollutants; Fluorocarbons; Oslo [Norway]; Matrix algebra; fluorophosphonic acid derivative; n ethyl perfluorooctanesulfonamide; n methyl perfluorooctanesulfonamide; organofluorine derivative; pefluorobutanesulfonate; pefluoroheptanoate; perfluoroalkanoic acid; perfluorodecanesulfonate; perfluorodecanoate; perfluorodecylphosphonate; perfluorododecanoate; perfluoroheptanesulfonate; perfluorohexanoic acid; perfluorohexylphosphonate; perfluorooctanesulfonamide; perfluorooctanesulfonic acid; perfluorooctanoic acid; perfluorooctylphosphonate; perfluoropentanoate; perfluorotetradecanoate; perfluorotridecanoate; perfluoroundecanoic acid; polyfluoroalkyl phosphate diester; polyfluoroalkyl phosphate ester; polyfluoroalkyl phosphate monoester; sulfonamide; unclassified drug; alkanesulfonic acid; fluorocarbon; Blood matrix; Composition profile; Concentration ratio; High frequency HF; Human serum blood; Perfluoroalkyl substances; Phosphate esters; Phosphonates; Substance concentrations; Whole blood; biochemical composition; chemical compound; concentration (composition); detection method; Article; bioaccumulation; biological monitoring; biotransformation; blood analysis; blood level; chemical composition; limit of detection; measurement accuracy; measurement precision; measurement repeatability; quality control; pollutant 
PFAS
• Additional PFAS (formerly XAgency)
     Literature Search November 2019
          Other Sources
               Reference list review of included studies
     Screened Studies
          Supplemental
• Expanded PFAS SEM (formerly PFAS 430)
     Sodium bis[2-(perfluorohexyl)ethyl] phosphate
• PFAS 150
     Literature Search Update December 2020
          PubMed
          WOS
     Literature Search August 2019
          PubMed
          Web of Science
     Screened Studies
          Supplemental
     Perfluorinated compounds
     Perfluorooctanesulfonamide
     Perfluorooctanesulfonate
     Perfluorooctanesulfonic acid
     Perfluoropropanoic acid
• PFAS Universe
     Data Source
          Web of Science
          Pubmed
     Perfluorohexanoate
     Perfluorohexanoic acid
     Perfluorohexyl phosphonic acid
     Perfluorooctanesulfonamide
     Perfluorooctanesulfonate
     Perfluorooctanesulfonic acid
     Perfluorooctanoate
     Perfluoropentanoic acid
     Perfluoropropanoic acid
     Sodium bis[2-(perfluorohexyl)ethyl] phosphate
     Perfluorooctanoic acid
• PFDA
     Scopus: April 2021
• PFHxA
     LitSearch Update: February 2018
          PubMed
          WoS
          Term Set 2: Initial Search
               PubMed
               WoS
     Literature Search
          Pubmed
          WOS
     Scopus: April 2021
     Title and Abstract Screening
          Full Text Screening
          Tagged as Supplemental
               ADME TK
     HAWC
• PFHxS
• PFNA
     Literature Search
          Toxline
     PFNA May 2019 Update
          Toxnet
     Title and Abstract Screening
          Tagged as Supplemental
               ADME
               Exposure assessment or qualitative exposure only
               Other PFAS
OW - HHRAB
• PFOA (335-67-1) and PFOS (1763-23-1)
     Literature Search Update (2013-2019)
          PubMed
          WOS
• PFOA and PFOS OW MCLG Approaches
     Cited in White Papers