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HERO ID
5063958
Reference Type
Journal Article
Title
Exploring sex differences in human health risk assessment for PFNA and PFDA using a PBPK model
Author(s)
Kim, SJ; Choi, EJ; Choi, GW; Lee, YB; Cho, HY
Year
2019
Is Peer Reviewed?
Yes
Journal
Archives of Toxicology
ISSN:
0340-5761
EISSN:
1432-0738
Publisher
SPRINGER HEIDELBERG
Location
HEIDELBERG
Volume
93
Issue
2
Page Numbers
311-330
Language
English
PMID
30483840
DOI
10.1007/s00204-018-2365-y
Web of Science Id
WOS:000457833300005
URL
http://link.springer.com/10.1007/s00204-018-2365-y
Exit
Relationship(s)
has comment/response
5412088
Comment on 'Kim, S.-J., Choi, E.-J., Choi, G.-W., Lee, Y.-B., and Cho, H.-Y. (2019)., Arch Toxicol 93:311-330'
Abstract
Perfluorononanoic acid (PFNA) and perfluorodecanoic acid (PFDA), which are classified as perfluoroalkyl and polyfluoroalkyl substances (PFASs), have been widely used in industrial applications as a surface protectant. PFASs have been detected in wildlife and in humans around the globe. The purposes of this study are to develop and validate a physiologically based pharmacokinetic (PBPK) model for detecting PFNA and PFDA in male and female rats, and to apply the model to a human health risk assessment regarding the sex difference. A PBPK model of PFNA and PFDA was established based on an in vivo study in male and female rats. Analytes in biological samples (plasma, nine tissues, urine, and feces) were determined by ultra-liquid chromatography coupled tandem mass spectrometry (UPLC-MS/MS) method. PFNA and PFDA showed a gender differences in the elimination half-life and volume of distribution. The tissue-plasma partition coefficients were the highest in the liver in both male and female rats. The predicted rat plasma and urine concentrations simulated and fitted were in good agreement with the observed values. The PBPK models of PFNA and PFDA in male and female rats were then extrapolated to a human PBPK model based on human physiological parameters. The external doses were calculated at 3.35 ng/kg/day (male) and 17.0 ng/kg/day (female) for PFNA and 0.530 ng/kg/day (male) and 0.661 ng/kg/day (female) for PFDA. Human risk assessment was estimated using Korean biomonitoring values considering the gender differences. This study provides valuable insight into human health risk assessment regarding PFNA and PFDA exposure.
Keywords
Environmental Studies--Toxicology And Environmental Safety; Perfluorononanoic acid (PFNA); Perfluorodecanoic acid (PFDA); Human health risk assessment; Gender differences; Mass spectrometry; Liquid chromatography; Analytical chemistry; Pharmacology; Biological properties; Biomonitoring; Risk assessment; Animal models; Perfluorodecanoic acid; Perfluoro compounds; In vivo methods and tests; Rodents; Computer simulation; Biological samples; Gender aspects; Sex differences; Industrial applications; Perfluoroalkyls; Tissues; Wildlife; Health risk assessment; Mass spectroscopy; Health risks
Tags
PFAS
•
Additional PFAS (formerly XAgency)
•
PFAS 150
Literature Search August 2019
PubMed
Web of Science
Not prioritized for screening
Perfluorodecanoic acid
Perfluorononanoic acid
Perfluorooctanoic acid
•
PFBA
Protocol References
•
PFBS
•
PFDA
Literature Search
Pubmed
Literature Search Update 5/2019
PubMed
Literature Search Update 4/2021
WoS
Scopus: April 2021
Title and Abstract Screening
Full Text Screening
Studies Meeting PECO
PBPK models
Literature Searches (through April 2023 update and post-public comment/peer review)a
Title & Abstract Screening
Tagged as Supplemental
Full Text Screening
Studies Meeting PECO
PBPK models
•
PFHxA
HAWC
•
PFHxS
•
PFNA
Literature Search
Pubmed
WOS
PFNA May 2019 Update
Pubmed
Web of Science
LitSearch: May 2019 - May 2020
WoS
Title and Abstract Screening
Full Text Screening
Studies Meeting PECO
Animal health effects studies
PBPK models
•
PFOA (335-67-1) and PFOS (1763-23-1)
Literature Search Update (2013-2019)
WOS
•
Yale PFAS Liver study
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