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Citation
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HERO ID
3230224
Reference Type
Journal Article
Title
Racial and ethnic variations in phthalate metabolite concentration changes across full-term pregnancies
Author(s)
James-Todd, TM; Meeker, JD; Huang, T; Hauser, R; Seely, EW; Ferguson, KK; Rich-Edwards, JW; Mcelrath, TF
Year
2017
Is Peer Reviewed?
Yes
Journal
Journal of Exposure Science & Environmental Epidemiology
ISSN:
1559-0631
EISSN:
1559-064X
Publisher
Nature Publishing Group
Volume
27
Issue
2
Page Numbers
160-166
Language
English
PMID
26860587
DOI
10.1038/jes.2016.2
Web of Science Id
WOS:000394456500001
URL
https://search.proquest.com/docview/1872837907?accountid=171501
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Abstract
Higher concentrations of certain phthalate metabolites are associated with adverse reproductive and pregnancy outcomes, as well as poor infant/child health outcomes. In non-pregnant populations, phthalate metabolite concentrations vary by race/ethnicity. Few studies have documented racial/ethnic differences between phthalate metabolite concentrations at multiple time points across the full-course of pregnancy. The objective of the study was to characterize the change in phthalate metabolite concentrations by race/ethnicity across multiple pregnancy time points. Women were participants in a prospectively collected pregnancy cohort who delivered at term (≥37 weeks) and had available urinary phthalate metabolite concentrations for ≥3 time points across full-term pregnancies (n=350 women). We assessed urinary concentrations of eight phthalate metabolites that were log-transformed and specific gravity-adjusted. We evaluated the potential racial/ethnic differences in phthalate metabolite concentrations at baseline (median 10 weeks gestation) using ANOVA and across pregnancy using linear mixed models to calculate the percent change and 95% confidence intervals adjusted for sociodemographic and lifestyle factors. Almost 30% of the population were non-Hispanic black or Hispanic. With the exception of mono-(3-carboxypropyl) (MCPP) and di-ethylhexyl phthalate (DEHP) metabolites, baseline levels of phthalate metabolites were significantly higher in non-whites (P<0.05). When evaluating patterns by race/ethnicity, mono-ethyl phthalate (MEP) and MCPP had significant percent changes across pregnancy. MEP was higher in Hispanics at baseline and decreased in mid-pregnancy but increased in late pregnancy for non-Hispanic blacks. MCPP was substantially higher in non-Hispanic blacks at baseline but decreased later in pregnancy. Across pregnancy, non-Hispanic black and Hispanic women had higher concentrations of certain phthalate metabolites. These differences may have implications for racial/ethnic differences in adverse pregnancy and child health outcomes.Journal of Exposure Science and Environmental Epidemiology advance online publication, 10 February 2016; doi:10.1038/jes.2016.2.
Keywords
Environment Abstracts; Toxicology Abstracts; Health & Safety Science Abstracts; Phthalic acid; Infants; Gestation; Phthalates; Pregnancy; Metabolites; Ethnic groups; ENA 02:Toxicology & Environmental Safety; X 24350:Industrial Chemicals; H 12000:Epidemiology and Public Health
Tags
IRIS
•
Dibutyl Phthalate (DBP)
Database Searches
Litsearch Jan 2016 - July 2016
Pubmed
LitSearch Jan 2017 - July 2017
Pubmed
Excluded: No Primary Data on Health Effects
Exposure levels
•
Diethyl phthalate (DEP)
Database searches
Jun 2016 update
Pubmed
Jul 2017 update
Web of Science
Jan 2020 update
PubMed
Web of Science
Excluded: No Primary Data on Health Effects
Exposure levels
•
Phthalates – Targeted Search for Epidemiological Studies
Source – all searches
Pubmed
WOS
Excluded
Source - Jun 2016 Update (Private)
Pubmed
Source - August 2017 Update (Private)
Pubmed
WOS
Source - August 2018 Update
WOS
Toxline
Level 1 Screen - Title & Abstract
Excluded
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