US EPA

3230224 

Journal Article 

Racial and ethnic variations in phthalate metabolite concentration changes across full-term pregnancies 

James-Todd, TM; Meeker, JD; Huang, T; Hauser, R; Seely, EW; Ferguson, KK; Rich-Edwards, JW; Mcelrath, TF 

2017 

Yes 

Journal of Exposure Science and Environmental Epidemiology
ISSN: 1559-0631
EISSN: 1559-064X 

27 

2 

160-166 

English 

26860587 

10.1038/jes.2016.2 

WOS:000394456500001 

https://search.proquest.com/docview/1872837907?accountid=171501
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Higher concentrations of certain phthalate metabolites are associated with adverse reproductive and pregnancy outcomes, as well as poor infant/child health outcomes. In non-pregnant populations, phthalate metabolite concentrations vary by race/ethnicity. Few studies have documented racial/ethnic differences between phthalate metabolite concentrations at multiple time points across the full-course of pregnancy. The objective of the study was to characterize the change in phthalate metabolite concentrations by race/ethnicity across multiple pregnancy time points. Women were participants in a prospectively collected pregnancy cohort who delivered at term (≥37 weeks) and had available urinary phthalate metabolite concentrations for ≥3 time points across full-term pregnancies (n=350 women). We assessed urinary concentrations of eight phthalate metabolites that were log-transformed and specific gravity-adjusted. We evaluated the potential racial/ethnic differences in phthalate metabolite concentrations at baseline (median 10 weeks gestation) using ANOVA and across pregnancy using linear mixed models to calculate the percent change and 95% confidence intervals adjusted for sociodemographic and lifestyle factors. Almost 30% of the population were non-Hispanic black or Hispanic. With the exception of mono-(3-carboxypropyl) (MCPP) and di-ethylhexyl phthalate (DEHP) metabolites, baseline levels of phthalate metabolites were significantly higher in non-whites (P<0.05). When evaluating patterns by race/ethnicity, mono-ethyl phthalate (MEP) and MCPP had significant percent changes across pregnancy. MEP was higher in Hispanics at baseline and decreased in mid-pregnancy but increased in late pregnancy for non-Hispanic blacks. MCPP was substantially higher in non-Hispanic blacks at baseline but decreased later in pregnancy. Across pregnancy, non-Hispanic black and Hispanic women had higher concentrations of certain phthalate metabolites. These differences may have implications for racial/ethnic differences in adverse pregnancy and child health outcomes.Journal of Exposure Science and Environmental Epidemiology advance online publication, 10 February 2016; doi:10.1038/jes.2016.2. 

Environment Abstracts; Toxicology Abstracts; Health & Safety Science Abstracts; Phthalic acid; Infants; Gestation; Phthalates; Pregnancy; Metabolites; Ethnic groups; ENA 02:Toxicology & Environmental Safety; X 24350:Industrial Chemicals; H 12000:Epidemiology and Public Health