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3858527 
Journal Article 
Preconception perfluoroalkyl and polyfluoroalkyl substances and incident pregnancy loss, LIFE Study 
Louis, GM; Sapra, KJ; Barr, DB; Lu, Z; Sundaram, R 
2016 
Reproductive Toxicology
ISSN: 0890-6238
EISSN: 1873-1708 
Elsevier 
OXFORD 
65 
Elsevier 
11-17 
English 
Equivocal findings are reported for perfluoroalkyl and polyfluoroalkyl substances (PFASs) and self-reported pregnancy loss. We prospectively assessed PFASs and pregnancy loss in a cohort comprising 501 couples recruited preconception and followed daily through 7 post-conception weeks. Seven PFASs were quantified: 2-N-ethyl-perfluorooctane sulfonamide acetate (Et-PFOSA-AcOH); 2-N-methyl-perfluorooctane sulfonamido acetate (Me-PFOSA-AcOH); perfluorodecanoate (PFDeA); perfluorononanoate (PFNA); perfluorooctane sulfonamide (PFOSA); perfluorooctane sulfonate (PFOS); and perfluorooctanoate (PFOA). Women used home pregnancy test kits. Loss denoted conversion from a positive to a negative pregnancy test, onset of menses or clinical confirmation (n=98; 28%). Chemicals were log transformed and rescaled by their standard deviations to estimate adjusted hazard ratios (HRs) and 95% confidence intervals. No significantly elevated HRs were observed for any PFASs suggesting no association with loss: Et-PFOSA-AcOH (1.04; 0.87, 1.23), Me-PFOSA-AcOH (0.79; 0.61, 1.00; p<0.05), PFDeA (0.83; 0.66, 1.04), PFNA (0.86; 0.70, 1.06), PFOSA (0.74; 0.50, 1.09), PFOS (0.81; 0.65, 1.00), and PFOA (0.93; 0.75, 1.16). 
Cohort; Epidemiology; Miscarriage; Perfluoroalkyl; Perfluoroalkyl acids; Polyfluoroalkyl; Pregnancy loss; Reproductive toxicity 
PFAS
• Additional PFAS (formerly XAgency)
     Literature Search November 2019
          PubMed
          Web of Science
          ToxNet
          Other Sources
               Reference list review of included studies
               TEDX
     Screened Studies
          Included
               Include (TIAB)
               Include (Full Text)
     2-(N-Ethyl-perfluorooctanesulfonamido)acetate
     2-(N-Methylperfluorooctanesulfonamido)acetate
     2-(N-Methylperfluorooctanesulfonamido)acetic acid
• Expanded PFAS SEM (formerly PFAS 430)
     Litsearch: September 2019
          PubMed
          Web of Science
          Other Sources
               PFAS TOX Database
     Screened Studies
          Excluded
               Exclude (TIAB)
     Not prioritized for screening
     Perfluorooctane
     Ethyl perfluorooctanoate
     2-(N-Ethylperfluorooctanesulfonamido)acetic acid
     2-(N-Methylperfluorooctanesulfonamido)acetate
     2-(N-Methylperfluorooctanesulfonamido)acetic acid
• NEtFOSAA
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          Pubmed
          WOS
     Screening Results
          Human/Epi studies
               Repro tox
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          Pubmed
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     Screening Results
          Human/Epi studies
               Repro tox
• ^Per- and Polyfluoroalkyl Substances (PFAS)
     PFOA (335-67-1) and PFOS (1763-23-1)
          Literature Search – Adverse outcome pathway (2015-present)
               Pubmed
               WOS
     PFDA (335-76-2)
          Literature Search
               Pubmed
               WOS
     PFNA (375-95-1)
          Literature Search
               Pubmed
               WOS
     PFOSA (754-91-6)
          Literature Search
               Pubmed
               WOS
     NEtFOSAA (2991-50-6)
          Literature Search
               Pubmed
               WOS
     NMeFOSAA (2355-31-9)
          Literature Search
               Pubmed
               WOS
• PFAS 150
     Literature Search Update December 2020
          PubMed
          WOS
     Literature Search August 2019
          PubMed
          Web of Science
          Other sources
               PFAS TOX Database
     Screened Studies
          Included
               Include (TIAB)
               Include (Full Text)
     Perfluorononanoic acid
     Perfluorooctane
     Perfluorooctanesulfonamide
     Perfluorooctanesulfonic acid
     Perfluorooctanoic acid
• PFAS Universe
     Data Source
          Web of Science
          Pubmed
          Screened Studies
               Excluded
                    Exclude (TIAB)
     2-(N-Ethylperfluorooctanesulfonamido)acetic acid
     2-(N-Methylperfluorooctanesulfonamido)acetate
     2-(N-Methylperfluorooctanesulfonamido)acetic acid
     Perfluorodecanoate
     Perfluorononanoate
     Perfluorooctane
     Perfluorooctanesulfonamide
     Perfluorooctanesulfonate
     Perfluorooctanesulfonic acid
     Perfluorooctanoate
     Perfluorooctanoic acid
• PFDA
     Literature Search
          Pubmed
          WOS
          Other
               Published PFAS SEMs
     Scopus: April 2021
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               Studies Meeting PECO
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               Full Text Screening
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     PFNA HAWC Readout
          Human
     Title and Abstract Screening
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                    Human health effects studies
     June 2022 Pelch Database
• PFOSA
     Literature Search
          Pubmed
          WOS
     Screening Results
          Human/Epi studies
               Repro tox
OW - HHRAB
• PFOA (335-67-1) and PFOS (1763-23-1)
     Literature Search – Adverse outcome pathway (2015-present)
          Pubmed
          WOS
     Screening Results
          Human/Epi studies
               Repro tox
     Literature Search Update (2013-2019)
          PubMed
          WOS
• PFOA and PFOS OW MCLG Approaches
     Cited in White Papers